Results 201 to 210 of about 5,040,431 (241)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

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Parameters of Erection

British Journal of Urology, 1984
Passive erection was obtained in 10 patients with normal erections without the use of any artificial mechanism of retention at the base of the penis. The necessary flow to provoke the erection ranged between 80 and 120 ml/min. Intracavernous pressure and penile circumference were also monitored until the appearance of a complete erection.
Wespes, Eric, Schulman, Claude
openaire   +3 more sources

Parameter estimation: local identifiability of parameters

American Journal of Physiology-Endocrinology and Metabolism, 1990
For biological systems one often cannot set up experiments to measure all of the state variables. If only a subset of the state variables can be measured, it is possible that some of the system parameters cannot influence the measured state variables or that they do so in combinations that do not define the parameters' effects separately.
J A, Jacquez, T, Perry
openaire   +2 more sources

Parameter by Parameter Algorithm for Multilayer Perceptrons

Neural Processing Letters, 2006
This paper presents a parameter by parameter (PBP) algorithm for speeding up the training of multilayer perceptrons (MLP). This new algorithm uses an approach similar to that of the layer by layer (LBL) algorithm, taking into account the input errors of the output layer and hidden layer.
Yanlai Li, David Zhang 0001, Kuanquan Wang   +2 more
openaire   +1 more source

MODFLOW‐Style Parameters in Underdetermined Parameter Estimation

Groundwater, 2011
In this article, we discuss the use of MODFLOW‐Style parameters in the numerical codes MODFLOW_2005 and MODFLOW_2005‐Adjoint for the definition of variables in the Layer Property Flow package. Parameters are a useful tool to represent aquifer properties
D'ORIA, Marco, Fienen, Michael N.
openaire   +3 more sources

Parameter sweeps for exploring GP parameters

Proceedings of the 7th annual conference on Genetic and evolutionary computation, 2005
This paper describes our procedure and a software application for conducting large parameter sweep experiments in genetic and evolutionary computation research. Both procedure and software allows a researcher to examine multivariate nonlinearities that are common in genetic and evolutionary computation.
Michael E. Samples, Jason M. Daida, Matthew J. Byom, Matt Pizzimenti   +3 more
openaire   +3 more sources