Results 111 to 120 of about 1,920,538 (274)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Parametric Structure Optimization of Bogie Frame Part Based on APDL
机车电传动, 2019 Aiming at improving the efficiency of modification and optimization for bogie frame part, a local parametric optimization method was proposed to optimize the structure of the supporting rib plate with transverse stops. The maximum von_Mises stress of the
Linhai WANG +3 more
doaj
Studia Geotechnica et MechanicaFrom a practical point of view, the most important feature of a parametric periodic system is the instability phenomenon. Unlike in systems with constant coefficients, in which only points of instability exist, in parametric systems, whole areas of ...
Wójcicki Zbigniew
doaj +1 more source
Fixed Point Results for Compatible Mappings in Extended Parametric Sb-Metric Spaces
MathematicsThis study aims to establish common fixed point theorems for a pair of compatible self-mappings within the framework of extended parametric Sb-metric spaces.
Sunil Beniwal +3 more
doaj +1 more source
Desimal, 2019 This study aims to discuss a linear program problem where its constants can change, If a constant for a linear program problem is changed, then we don't need to count from the beginning again.
Adolf T Simatupang
doaj +1 more source
Parametric gravity wave detector [PDF]
, 2001 Since 1978 superconducting coupled cavities have been proposed as a sensitive detector of gravitational waves. The interaction of the gravitational wave with the cavity walls, and the esulting motion, induces the transition of some energy from an ...
Bernard, Ph. +4 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Studia Geotechnica et MechanicaThe work presents a method of automatic stabilisation of unstable multi-degree-of-freedom linear parametric systems. The publication is a continuation and extension of the subject matter described in Wójcicki’s earlier work ‘Application of first-order ...
Wójcicki Zbigniew
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source