Results 131 to 140 of about 566,338 (299)
Advanced Science, EarlyView.TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao +8 more
wiley +1 more source
Measuring efficiency of Tunisian schools in the presence of quasi-fixed inputs: A bootstrap data envelopment analysis approach [PDF]
The objective of this paper is to measure the efficiency of high schools in Tunisia. We use a statistical Data Envelopment Analysis (DEA)-bootstrap approach with quasi-fixed inputs to estimate the precision of our measure.
Essid, Hédi +2 more
core
Advanced Science, EarlyView.CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin +17 more
wiley +1 more source
A note on the Bandwidth choice when the null hypothesis is semiparametric [PDF]
This work presents a tool for the additivity test. The additive model is widely used for parametric and semiparametric modeling of economic data. The additivity hypothesis is of interest because it is easy to interpret and produces reasonably fast ...
Jorge Barrientos Marín
core
Advanced Science, EarlyView.A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang +9 more
wiley +1 more source
The Size and Power of Bootstrap Tests [PDF]
Bootstrap tests are tests for which the significance level is calculated by some sort of bootstrap procedure, which may be parametric or nonparametric. We show that, in many circumstances, the size distortion of a bootstrap P value for a test will be one
Russell Davidson, James G. MacKinnon
core
Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges
Advanced Science, EarlyView.Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen +6 more
wiley +1 more source
INTRODUCING MODEL UNCERTAINTY IN TIME SERIES BOOTSTRAP [PDF]
It is common in parametric bootstrap to select the model from the data, and then treat it as it were the true model. Kilian (1998) have shown that ignoring the model uncertainty may seriously undermine the coverage accuracy of bootstrap confidence ...
Andrés M. Alonso +2 more
core
Science and Technology IndonesiaLifetime data are involved in numerous applied sciences, and the extended Rama (ER) distribution can be used to model such data. The maximum likelihood method is widely used for estimating the parameters of any distribution, particularly with large ...
Chanakan Sungboonchoo
doaj +1 more source
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source