Results 41 to 50 of about 35,984 (255)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

On Testing the Adequacy of the Inverse Gaussian Distribution

open access: yesMathematics, 2022
We propose a new class of goodness-of-fit tests for the inverse Gaussian distribution based on a characterization of the cumulative distribution function (CDF). The new tests are of weighted L2-type depending on a tuning parameter.
James S. Allison   +3 more
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi   +9 more
wiley   +1 more source

Selected Statistical Tests for Median and Their Properties

open access: yesActa Universitatis Lodziensis. Folia Oeconomica, 2017
In the paper, a selection of statistical tests for median are presented. In particular, parametric and nonparametric significance tests are considered.
Dorota Pekasiewicz, Agata Szczukocka
doaj   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch   +5 more
wiley   +1 more source

Biopsychosocial Determinants of Hand Function and Its Trajectories Over Five Years in Patients With Hand Osteoarthritis

open access: yesArthritis Care &Research, EarlyView.
Objective This study aimed to investigate hand function trajectories over five years in primary hand osteoarthritis (OA). Additionally, determinants of baseline and longitudinal hand function were assessed. Methods A total of 538 patients with both baseline and five‐year study visits were analyzed.
Annemiek V. E. M. Olde Meule   +4 more
wiley   +1 more source

Parametric and nonparametric bootstrap methods for general MANOVA

open access: yesJournal of Multivariate Analysis, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Frank Konietschke   +3 more
openaire   +1 more source

Uncertainties in sampling procedures for age composition of hake and sardine in Iberian Atlantic waters

open access: yesScientia Marina, 2004
Estimates of the age composition of hake (demersal) and sardine (pelagic) in Iberian Atlantic waters in 1999 are analysed, paying specific attention to sampling variability.
Ernesto Jardim   +2 more
doaj   +1 more source

Simultaneous Inference of Gene Isoform Expression for RNA Sequencing Data

open access: yesRevstat Statistical Journal, 2020
In this article, we describe simultaneous inferential methods in detecting differentially expressed gene isoforms based on the Poisson generalized linear models. We derive the joint asymptotic distribution of pivotal quantities.
Bo Li
doaj   +1 more source

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