Results 141 to 150 of about 553,512 (210)

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Small area estimation on poverty indicators [PDF]

We propose to estimate non-linear small area population quantities by using Empirical Best (EB) estimators based on a nested error model. EB estimators are obtained by Monte Carlo approximation.
J.N.K. Rao, Isabel Molina
core  

LigHTS: Biomimetic Hydrogel Photo‐Fabrication for Imaging‐Based Ultra‐High‐Throughput Screening

Advanced Science, EarlyView.
LigHTS removes a key bottleneck for ultra‐high‐throughput screening (UHTS) by enabling biomimetic hydrogel microenvironments to be manufactured directly in standard multiwell plates. A single, collimated UV exposure with formulation‐tuned light penetration patterns an entire plate with UHTS‐grade uniformity (<20% CV), producing structured GelMA films ...
Alessandro Enrico, Sara Rigolli, Julius Zimmermann, Melissa Pezzotti, Eloisa Torchia, Moises Di Sante, Ferdinando Auricchio, Francesco S. Pasqualini   +7 more
wiley   +1 more source

Disabling COMPASS Promoter Licensing Shifts HDAC‐Inhibited Gastric Cancer Toward Sustained Transcriptional Suppression During Recovery

Advanced Science, EarlyView.
Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song, Hui Yu, Jianping Jiang, Zhihui Jiang, Zhongshi Hong, Xu Zhang, Luchuan Chen, Shenghong Wei, Yi Wang   +8 more
wiley   +1 more source

Efficiency of the Portuguese metros. is it different from other European metros? [PDF]

This research analyses the performance of Portuguese metros in the European context. By means of two non-parametric benchmarking techniques, respectively performance indicators and data envelopment analysis, we compute the efficiency of 37 European ...
Simões, Pedro, Costa, Álvaro, Santos, Joana, Cunha Marques, Rui   +3 more
core  

Serial H&E Pathology Reveals Progression‐Associated Nuclear Size Drift as a Longitudinal Digital Readout of Bladder Cancer Evolution

Advanced Science, EarlyView.
Routine serial H&E specimens from bladder cancer are converted into paired T0/T1 digital pathology readouts of tumor evolution. Progression is associated with longitudinal nuclear drift, with nuclear size‐related changes most evident in the independent confirmation cohort, alongside a broader spatial burden of increased nuclear area and biological ...
Xing Liu, Zhen‐Duo Shi, Gong‐Cheng Wang, Jian‐Ming Wang, Ying Liu, Yi Gong, Xuan Lin, Di Wu, Shi‐Chao Zhuo, Han Han, Yi‐Bing Shi, Fan‐Lai Meng, Yu Zhang, Zhi‐Gang Jia, Cong‐Hui Han   +14 more
wiley   +1 more source

Symptom‐Driven Prediction of Chronic Multimorbidity with a Macro–Micro Heterogeneous Graph Neural Network

Advanced Science, EarlyView.
Clinical symptoms offer a window into multimorbidity. A macro‐micro heterogeneous graph neural network integrates clinical records with biomedical knowledge to improve patient‐level symptom‐disease association learning and visit‐level multimorbidity completion.
Yiheng Ye, Miaoru Han, Siqiao Tang, Zongxiang Zhang, Haichen Shen, Bingzhen Sun, Yan Zhang, Xiaodong Chu, Lijuan Deng, Chaoyang Zheng, Qingchun Huang, Kun Bao, Ronghua Zhang, Yong Wang, Fengwei Zhang, Xiaoli Chu   +15 more
wiley   +1 more source

Breakdown Point Theory for Implied Probability Bootstrap [PDF]

This paper studies robustness of bootstrap inference methods under moment conditions. In particular, we compare the uniform weight and implied probability bootstraps by analyzing behaviors of the bootstrap quantiles when outliers take arbitrarily large ...
Lorenzo Camponovo, Taisuke Otsu
core  

Flooding‐Driven Greenhouse Gas Emissions From Global Upland Croplands

Advanced Science, EarlyView.
Temporary flooding of upland croplands releases nitrous oxide, carbon dioxide, and methane. Field measurements combined with a global literature synthesis yield a global estimate of 63.3 teragrams of carbon dioxide equivalent per year for diffusive emissions from flooded upland croplands.
Shuilian Bi, Zhifeng Yan, Zhengkui Ge, Si‐Liang Li, Guirui Yu, Cong‐Qiang Liu, Hanqin Tian, Pete Smith   +7 more
wiley   +1 more source

Mechanochemically Disordered Li2Ta2OCl10 Oxyhalide Unlocks Superionic Conductivity (>10 mS.cm−1)

Advanced Energy Materials, EarlyView.
This work presents a new crystalline oxyhalide, Li2Ta2OCl10, built from [Ta2OCl10]2− dimers. The disorder induced by ball‐milling drives the dramatic 5000‐fold increase in ionic conductivity to reach 11 mS.cm−1. The material shows promise as a solid electrolyte for batteries and opens new prospects for the discovery of new dimer‐based compounds ...
Clément Morel, Anshuman Chaupatnaik, Jie Liu, Mingxue Tang, Horyung Ji, Mouna Ben Yahia, Marie‐Liesse Doublet, Tatiana N. Kobernik, Dmitry A. Aksyonov, Artem M. Abakumov, Gwenaëlle Rousse, Jean‐Marie Tarascon   +11 more
wiley   +1 more source