Results 91 to 100 of about 16,494,859 (301)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
DOE Based Parametric Study of Volumetric Change of FDM Parts
, 2014 Investigation into the part accuracy in the Fused Deposition Modeling (FDM), which is one of the most successful Additive Manufacturing (AM) technologies and continues to dominate the world as one of the few processes suitable for manufacturing both ...
P. Gurrala, S. Regalla
semanticscholar +1 more source
Theoretical and Applied Climatology, 2019 This study aims to investigate the precipitation trends in Keszthely (Western Hungary, Central Europe) through an examination of historical climate data covering the past almost one and a half centuries.
T. Kocsis, I. Kovács-Székely, A. Anda
semanticscholar +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Desimal, 2019 This study aims to discuss a linear program problem where its constants can change, If a constant for a linear program problem is changed, then we don't need to count from the beginning again.
Adolf T Simatupang
doaj +1 more source
Detection of parametric changes in autoregressive fields
, 1995 The quickest detection problem is formulated for processes defined on a two-dimensional lattice.
Hupkens, Erik P., Bagchi, Arunabha
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Climate conscious design of light structures for improving the liveability of urban environments
TechneA climate-neutral urban environment can benefit from light structures that provide relief from urban overheating in warm seasons, reduce surface temperatures, and lower energy needs and carbon emissions while sequestering carbon through bio-based ...
Rossella Siani, Francesco De Luca
doaj +1 more source