Results 151 to 160 of about 1,068,788 (332)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Atracción de lo virtual, voluntad de lo real
ARQ, 2006 La incorporación de las herramientas digitales en los procesos constructivos es relativamente nueva. El traspaso desde el campo proyectual hacia el de la obra es la primera manifestación de un proceso que apenas comienza, y que debiera alimentar la ...
Juan Ignacio Baixas
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Modeling Parametric Vibration Of Multistage Gear Systems As A Tool For Design Optimization
, 2008 James Kuria, John Kihiu
openalex +1 more source
Efficiency of an Improved Grouted Corrugated Duct (GCD) Connection Design for Precast Concrete Bridge Pier: Numerical and Parametric Study [PDF]
, 2023 Zhiqiang Wang +3 more
openalex +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Parametric design and BIM, systemic tools for circular architecture [PDF]
, 2019 Charlotte Dautremont +3 more
openalex +1 more source
Multi-Objective Optimization Design of Assembled Wheel Lightweight Based on Implicit Parametric Method and Modified NSGA-II [PDF]
, 2023 Shuai Zhang +4 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Applied SciencesThis study aimed to improve the mechanical properties of 3D concept designs by combining the design capability of a generative adversarial network with finite element analysis.
Nurullah Yüksel +1 more
doaj +1 more source