Results 221 to 230 of about 702,666 (251)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

TAUS: Target-Age Unified Survival. Survival Analysis Without Assuming Proportional Hazards or Parameterising the Survival Function. [PDF]

Ecol Evol
Casas Gomez-Uribarri I, Babayan SA, Okumu F, Baldini F, Betancourth MP.   +4 more
europepmc   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

A novel DIO optimized sigmoid-activated 2DOF-PID controller for robust control of magnetic levitation systems. [PDF]

Sci Rep
Ökten İ.
europepmc   +1 more source

DySurv: dynamic deep learning model for survival analysis with conditional variational inference. [PDF]

J Am Med Inform Assoc
Mesinovic M, Watkinson P, Zhu T.
europepmc   +1 more source

Optimizing decision making with Fermatean fuzzy soft Hamachar operators in the analysis of anaphylaxis (a life-threatening allergic reaction). [PDF]

Sci Rep
Zeb A, Ali N, Riaz M, Zhao H, Mahboob M, Hou M.   +5 more
europepmc   +1 more source

Demystifying Prediction-Powered Inference. [PDF]

Harv Data Sci Rev
Song Y, Kluger DM, Parikh H, Gu T.
europepmc   +1 more source

Expert-Driven Survival Machines: Improving Stratification and Interpretability in Multiple Clinical Cohorts. [PDF]

ACM BCB
Zhuang F, Wen Z, Davatzikos C, Shen L.
europepmc   +1 more source