Results 111 to 120 of about 21,287 (304)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Efficiency of the Portuguese metros. is it different from other European metros?
This research analyses the performance of Portuguese metros in the European context. By means of two non-parametric benchmarking techniques, respectively performance indicators and data envelopment analysis, we compute the efficiency of 37 European ...
Simões, Pedro +3 more
core
The Estimation of Stochastic Cost Functions of Malaysian Commercial Banks and Its Policy Implications to Bank Restructuring [PDF]
The present paper examines stochastic cost functions of Malaysian commercial banks from 1991 to 1997 periods and catches the changes in their management structure and technical efficiency.
Murakami, Michiko +2 more
core
Social Media and Politeness in Adolescent Language Practices: A Sociolinguistic Perspective
SALEEThis study aims to analyze the relationship between social media use and language politeness among students at SMP N 222 East Jakarta, considering that social media serves as a socialization space that influences teenagers’ linguistic interactions.
Dery Saefudin +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Biomechanics and Modeling in MechanobiologyAbstractThe vast majority of heart attacks occur when vulnerable plaques rupture, releasing their lipid content into the blood stream leading to thrombus formation and blockage of a coronary artery. Detection of these unstable plaques before they rupture remains a challenge.
Shaolie S. Hossain +2 more
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Cosmological implications of quantum mechanics parametrization of dark energy [PDF]
Journal of Physics: Conference Series, 2017 Szydłowski, Marek +2 more
openaire +2 more sources
American Journal of NeuroradiologyFDG-PET is critical in the diagnosis of neurodegenerative disease. Quantitative analysis with statistical parametric mapping (SPM) has been shown to improve the diagnostic accuracy of FDG-PET and has been incorporated in clinical workflows. This study aimed to assess the effects of hydrocephalus on the accuracy of FDG-PET SPM analysis, focusing on the ...
Andres Ricaurte-Fajardo +12 more
openaire +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source