Results 11 to 20 of about 11,644 (223)
Type inference with partial types [PDF]
, 1994 As a partial solution to the problem of combining static and dynamic typing in a language with parametric polymorphism, this paper introduces a new form of type expressions which represent partial type information.
Thatte, Satish R.
core +1 more source
Non-parametric spatial curvature inference using late-Universe cosmological probes [PDF]
, 2021 Inferring high-fidelity constraints on the spatial curvature parameter, ΩK, under as few assumptions as possible, is of fundamental importance in cosmology. We propose a method to non-parametrically infer ΩK from late-Universe probes alone.
Dhawan, Suhail +3 more
core +1 more source
Estimation and inference under economic restrictions [PDF]
, 2014 Estimation of economic relationships often requires imposition of constraints such as positivity or monotonicity on each observation. Methods to impose such constraints, however, vary depending upon the estimation technique employed.
Parmeter, Christopher F. +10 more
core +1 more source
Semiparametric inference with shape constraints [PDF]
, 2016 This thesis deals with estimation and inference in two semiparametric problems: a two-component mixture model and a single index regression model. For the two-component mixture model, we assume that the distribution of one component is known and ...
Patra, Rohit Kumar
core +2 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Communication-Efficient Distribution-Free Inference Over Networks [PDF]
, 2023 Consider a star network where each local node possesses a set of test statistics that exhibit a symmetric distribution around zero when their corresponding null hypothesis is true.
Xiang, Yu, Pournaderi, Mehrdad
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source