Results 171 to 180 of about 14,495,757 (308)

Using Bayesian Nonparametric Item Response Function Estimation to Check Parametric Model Fit. [PDF]

Appl Psychol Meas, 2020
Wang W, Kingston N.
europepmc   +1 more source

A test for model specification of diffusion processes [PDF]

We propose a test for model specification of a parametric diffusion process based on a kernel estimation of the transitional density of the process. The empirical likelihood is used to formulate a statistic, for each kernel smoothing bandwidth, which is ...
Gao, Jiti, Tang, Chenghong, Chen, Song Xi   +2 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Estimating a semi-parametric duration model without specifying heterogeneity [PDF]

This paper presents a new estimator for the mixed proportional hazard model that allows for a nonparametric baseline hazard and time-varying regressors.
Tiemen M. Woutersen, Jerry Hausman
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

New Parametric Model for Estimating the Viscosity of Choline Chloride-Based Deep Eutectic Solvents and Their Aqueous Mixtures. [PDF]

Molecules
Mokraoui S, Wazeer I, El Blidi L, Koura IME, Hadj-Kali MK.   +4 more
europepmc   +1 more source

Semi-parametric model for timing of first childbirth after HIV diagnosis among women of childbearing age in Ibadan, Nigeria. [PDF]

PLoS One, 2020
Akinyemi JO, Afolabi RF, Awolude OA.
europepmc   +1 more source

new test for the parametric form of the variance function in nonparametric regression [PDF]

In the common nonparametric regression model the problem of testing for the parametric form of the conditional variance is considered. A stochastic process based on the difference between the empirical processes obtained from the standardized ...
Dette, Holger, van Keilegom, Ingrid
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

PERSONALIZED RISK PREDICTION FOR CANCER SURVIVORS: A GENERALIZED BAYESIAN SEMI-PARAMETRIC MODEL OF RECURRENT EVENTS WITH COMPETING OUTCOMES. [PDF]

Ann Appl Stat
Nguyen NH, Shin SJ, Dodd-Eaton E, Ning J, Wang W.   +4 more
europepmc   +1 more source