Results 51 to 60 of about 60,070 (303)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Application of Freeform Surface to the Parametric Design of Plate Sheet Structure

open access: yesChemical Engineering Transactions, 2018
This paper constructs a small-scale, lightweight structure with complex freeform surfaces via parametric design. First, the method of freeform surface modelling and parametric design were introduced, and combined into the parametric design aided freeform
Wei Zhang   +3 more
doaj   +1 more source

Comparison of Parametric and Semi-Parametric Binary Response Models [PDF]

open access: yesSSRN Electronic Journal, 2013
A Bayesian semi-parametric estimation of the binary response model using Markov Chain Monte Carlo algorithms is proposed. The performances of the parametric and semi-parametric models are presented. The mean squared errors, receiver operating characteristic curve, and the marginal effect are used as the model selection criteria.
Xiangjin Shen   +2 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

GDP nowcasting with ragged-edge data : A semi-parametric modelling [PDF]

open access: yes
This papier formalizes the process of forecasting unbalanced monthly data sets in order to obtain robust nowcasts and forecasts of quarterly GDP growth rate through a semi-parametric modelling.
Patrick Rakotomarolahy   +2 more
core   +1 more source

Stripped and layered fabrication of minimal surface tectonics using parametric algorithms

open access: yesCurved and Layered Structures, 2023
This article describes a parametric design and fabrication workflow influenced by Frei Otto’s form-finding experiments on soap films. The research investigates minimal surface geometry by combining physical and digital experiments in a computational ...
Gokmen Sabri
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Conceptual Design of Compliant Structures for Morphing Wingtips Using Single-Row Corrugated Panels

open access: yesAerospace
Morphing wingtips have the potential to improve aircraft performance. By connecting the wingtips and the wings with a compliant structure, a continuous aerodynamic surface can be achieved for a better aerodynamic performance. However, how to maintain the
Ziyi He   +6 more
doaj   +1 more source

Towards a parametric plug-in for conservation of built heritage

open access: yesAlexandria Engineering Journal, 2019
It is an undeniable fact that heritage buildings are a valuable asset for society, it reveals their achievements over the years. Therefore, the need to conserve built heritage has become an increasingly urgent case to experts and the community, they ...
Heba Allah Abd ElWahab   +2 more
doaj   +1 more source

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