Results 161 to 170 of about 379,530 (310)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Boosting the accuracy of hedonic pricing models

Hedonic pricing models attempt to model a relationship between object attributes andthe object's price. Traditional hedonic pricing models are often parametric models that sufferfrom misspecification.
Kagie, M., Potharst, R., Wezel, M.C. van
core  

Construction of complex non-uniform rational B-spline volume parametric models with G¹ continuity. [PDF]

Vis Comput Ind Biomed Art
Wang D, Chen L, Zhang J.
europepmc   +1 more source

Broadband lung dielectric properties over the ablative temperature range: Experimental measurements and parametric models. [PDF]

Med Phys, 2019
Sebek J, Bortel R, Prakash P.
europepmc   +1 more source

The relative survival and cure fraction of gastric cancer estimated through flexible parametric models using data from population-based cancer registration during 2003-2012 in Linzhou, China. [PDF]

Cancer Med, 2020
Chen Q, Liu SZ, Zhang SK, Cao XQ, Li BY, Quan PL, Guo LW, Dong L, Sun XB, Zhang Y, Zhang JG.   +10 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

BSD: A Bayesian Framework for Parametric Models of Neural Spectra. [PDF]

Eur J Neurosci
Medrano J, Alexander NA, Seymour RA, Zeidman P.   +3 more
europepmc   +1 more source

Parametric models for biomarkers based on flexible size distributions. [PDF]

Health Econ, 2018
Davillas A, Jones AM.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pairwise Comparison Estimation of Censored Transformation Models [PDF]

In this paper a pairwise comparison estimation procedure is proposed for the regression coefficients in a censored transformation model. The main advantage of the new estimator is that it can accommodate covariate dependent censoring without the ...
Elie Tamer, Shakeeb Khan
core