Results 101 to 110 of about 461,827 (310)

Detection thresholding using mutual information [PDF]

, 2006
In this paper, we introduce a novel non-parametric thresholding method that we term Mutual-Information Thresholding. In our approach, we choose the two detection thresholds for two input signals such that the mutual information between the thresholded ...
Cooke, Eddie, O'Connor, Noel E., Smeaton, Alan F., Ó Conaire, Ciarán   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Stochastic Search for a Parametric Cost Function Approximation: Energy storage with rolling forecasts [PDF]

, 2022
Saeed Ghadimi, Warren B. Powell
openalex   +1 more source

The Relative Efficiency of Active Labour Market Policies: Evidence from a Social Experiment and Non-Parametric Methods [PDF]

We re-analyze the effects of a Danish active labour market program social experiment that included a range of sub-treatments, including monitoring, job search assistance and training.
Rosholm, Michael, Svarer, Michael, Vikström, Johan   +2 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Model evaluation and selection in multiple nonlinear regression analysis

Mathematical Modelling and Analysis, 2007
The main problem in regression model selection is finding the best model that best fits the data, i.e. it does not neither overfit nor underfit. The aim of this work is to show one of possible ways to find adequate nonlinear regression models (parametric)
Gints Jēkabsons, Jurijs Lavendels, Vjaceslavs Sitikovs   +2 more
doaj   +1 more source

Pruning and Nonparametric Multiple Change Point Detection

, 2017
Change point analysis is a statistical tool to identify homogeneity within time series data. We propose a pruning approach for approximate nonparametric estimation of multiple change points.
James, Nicholas, Matteson, David, Zhang, Wenyu   +2 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Future Prediction for Tax Complaints to Turkish Ombudsman by Models from Polynomial Regression and Parametric Distribution

Chaos Theory and Applications
The aim of this study is to forecast the amount of tax complaints filed with the Turkish Ombudsman in the future and whether or not policymakers require a specific tax Ombudsman.
Mehmet Niyazi Çankaya, Murat Aydın
doaj   +1 more source