Results 111 to 120 of about 461,827 (310)

On the Identification of the Costs of Simultaneous Search [PDF]

open access: yes
This paper studies the identification of the costs of simultaneous search in a class of (portfolio) problems studied by Chade and Smith (2006). We show that aggregate data from a single market, or disaggregate data from a single market segment, do not ...
Jose Luis Moraga-Gonzalez   +2 more
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Hospital performance evaluation models: A scoping review

open access: yesJournal of Education and Health Promotion
Evaluating the performance of hospitals, the largest budget consumers of the health system, is challenging. This scoping review aimed to identify and classify hospital performance evaluation models and their dimensions.
Shirin Alsadat Hadian   +4 more
doaj   +1 more source

Optimal Parametric Search on Graphs of Bounded Tree-Width

open access: yesJournal of Algorithms, 1994
Summary: We give linear-time algorithms for a class of parametric search problems on weighted graphs of bounded tree-width. We also discuss the implications of our results to approximate parametric search on planar graphs.
Fernández-Baca, David, Slutzki, Giora
openaire   +4 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Measuring the efficiency in spanish municipal refuse collection services [PDF]

open access: yes
The objective of this study is to analyse the technical or productive efficiency of the refuse collection services in 75 municipalities located in the Spanish region of Catalonia. The analysis has been carried out using various techniques.
Francisco Pedraja   +2 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Dark Matter Axion Search Using a Josephson Traveling Wave Parametric Amplifier [PDF]

open access: green, 2021
C. Bartram   +50 more
openalex   +1 more source

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