Results 51 to 60 of about 81,834 (245)
Mathematics, 2023 The Squirrel Search Algorithm (SSA) is widely used due to its simple structure and efficient search ability. However, SSA exhibits relatively slow convergence speed and imbalanced exploration and exploitation.
Lei Chen, Bingjie Zhao, Yunpeng Ma
doaj +1 more source
A Parametric Framework for Cooperative Parallel Local Search [PDF]
, 2014 In this paper we address the problem of parallelizing local search. We propose a general framework where different local search engines cooperate (through communication) in the quest for a solution. Several parameters allow the user to instantiate and customize the framework, like the degree of intensification and diversification.
Munera, Danny +3 more
openaire +3 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Enriching Non-Parametric Bidirectional Search Algorithms
Proceedings of the AAAI Conference on Artificial Intelligence, 2019 NBS is a non-parametric bidirectional search algorithm proven to expand at most twice the number of node expansions required to verify the optimality of a solution. We introduce new variants of NBS that are aimed at finding all optimal solutions. We then introduce an algorithmic framework that includes NBS as a special case. Finally, we introduce DVCBS,
Shahaf S. Shperberg +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
PS-GO parametric protein search engine
Computational and Structural Biotechnology JournalWith the explosive growth of protein-related data, we are confronted with a critical scientific inquiry: How can we effectively retrieve, compare, and profoundly comprehend these protein structures to maximize the utilization of such data resources? PS-GO, a parametric protein search engine, has been specifically designed and developed to maximize the ...
Yanlin Mi +3 more
openaire +2 more sources
Parametrics of electromagnetic searches for axion dark matter [PDF]
Physical Review D, 2021 27 pages, 3 figures; v5: matches version to appear in ...
openaire +2 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Revista Brasileira de Cancerologia, 2023 Introduction: Internet users frequently search for information on health issues. The behavior of Internet users may be related to health contexts experienced in their communities, reflecting unmet demands.
Ricardo Barbosa Lima +5 more
doaj +1 more source