Results 81 to 90 of about 461,827 (310)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
In search of a unifying theory of white matter aging: improving the understanding of tract-wise degeneration using multi-parametric signatures of morphometry and microstructure [PDF]
, 2023 Tyler D. Robinson +3 more
openalex +1 more source
Active Sensing as Bayes-Optimal Sequential Decision Making [PDF]
, 2013 Sensory inference under conditions of uncertainty is a major problem in both machine learning and computational neuroscience. An important but poorly understood aspect of sensory processing is the role of active sensing.
Ahmad, Sheeraz, Yu, Angela J.
core +1 more source
Majorana-Like Modes of Light in a One-Dimensional Array of Nonlinear Cavities
, 2012 The search for Majorana fermions in p-wave paired fermionic systems has recently moved to the forefront of condensed-matter research. Here we propose an alternative route and show theoretically that Majorana-like modes can be realized and probed in a ...
A. İmamoǧlu, C.-E. Bardyn, Y. Yamamoto
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Concurrent Multi-Robot Search of Multiple Missing Persons in Urban Environments
RoboticsCoordinating robotic teams across multiple concurrent search tasks is a critical challenge in search and rescue operations. This work presents a new multi-agent framework designed to manage and optimize search efforts when several missing-person reports ...
Zicheng Wang, Beno Benhabib
doaj +1 more source
Diameter, width, closest line pair, and parametric searching [PDF]
Proceedings of the eighth annual symposium on Computational geometry - SCG '92, 1992 We apply Megiddo's parametric searching technique to several geometric optimization problems and derive significantly improved solutions for them. We obtain, for any fixed \(\varepsilon>0\), an \(O(n^{1+\varepsilon})\) algorithm for computing the diameter of a point set in 3-space, an \(O(^{8/5+\varepsilon})\) algorithm for computing the width of such ...
Chazelle, Bernard +3 more
openaire +2 more sources
Measuring the efficiency in Spanish municipal refuse collection services [PDF]
, 1999 The objective of this study is to analyse the technical or productive efficiency of the refuse collection services in 75 municipalities located in the Spanish region of Catalonia. The analysis has been carried out using various techniques.
Bosch Roca, Núria +2 more
core
Spatial correlations in parametric down-conversion
, 2010 The transverse spatial effects observed in photon pairs produced by parametric down-conversion provide a robust and fertile testing ground for studies of quantum mechanics, non-classical states of light, correlated imaging and quantum information.
Monken, C. H. +3 more
core +1 more source