Results 121 to 130 of about 767,689 (294)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Testing for cointegration using induced-order statistics. [PDF]
In this paper we explore the usefulness of induced-order statistics in the characterization of integrated series and of cointegration relationships. We propose a non-parametric test statistic for testing the null hypothesis of two independent random ...
Escribano, Álvaro +2 more
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Orientation Statistics Without Parametric Assumptions
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1986 SUMMARY Maximum likelihood estimation using the matrix von Mises-Fisher distribution in orientation statistics leads to unacceptably complicated likelihood equations, essentially because of the inconvenient form of the normalizing constant in the probability distribution.
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Less parametric methods in statistics
Advances in Methodology and Statistics, 2005 Despite forty years of revolution in the tools available for statistical analysis, the current academic tradition in statistics is remarkably similar to the pre-computer tradition. This tradition is rooted in parametric modeling, estimation, and testing, and optimal procedures based on these models.
openaire +4 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Biological parametric mapping with robust and non-parametric statistics. [PDF]
Neuroimage, 2011 Yang X +3 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
A Study on the Yield Stability of Oilseed Sunflower Genotypes under Drought Stress [PDF]
پژوهشنامه اصلاح گیاهان زراعیExtended Abstract Background: The process of selecting and introducing compatible genotypes with high yield potential requires evaluation in different years and places.
Nasrin Akbari, Reza Darvishzadeh
doaj