Results 81 to 90 of about 2,433,231 (260)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Non-parametric estimation of ROC curve

, 2006
Receiver operating characteristic (ROC) curve is widely applied in measuring discriminatory ability of diagnostic or prognostic tests. This makes ROC analysis one of the most actively research areas in medical statistics.
Gu, Jiezhun, Ghosal, Subhashis, Roy, Anindya   +2 more
core  

Department of Applied Mathematics and Statistics newsletter, October 23, 2023 [PDF]

, 2023
Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...

core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Limit Laws for Sums of Logarithms of k-Spacings

Entropy
Let Z=Z1,…,Zn be an i.i.d. sample from the absolutely continuous distribution function F(z):=P(Z≤z), with density f(z):=ddzF(z).
Paul Deheuvels
doaj   +1 more source

Three Similarity Measures between One-Dimensional DataSets

Revista Colombiana de Estadística, 2014
Based on an interval distance, three functions are given in order to quantify similarities between one-dimensional data sets by using first-order statistics.
LUIS GONZALEZ-ABRIL, JOSE M. GAVILAN, FRANCISCO VELASCO MORENTE   +2 more
doaj   +1 more source

Photon statistics of pulsed parametric light

, 1998
We calculate and measure the photon statistics of weak light pulses emitted in the process of pulsed parametric down-conversion. We find photon bunching as expected from a chaotic light source when viewed through a narrow-band filter.
Rarity, J G, Tapster, P R
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Hepatic Steatosis Assessment Using Quantitative Ultrasound Parametric Imaging Based on Backscatter Envelope Statistics

Applied Sciences, 2019
Hepatic steatosis is a key manifestation of non-alcoholic fatty liver disease (NAFLD). Early detection of hepatic steatosis is of critical importance. Currently, liver biopsy is the clinical golden standard for hepatic steatosis assessment.
Zhuhuang Zhou, Qiyu Zhang, Weiwei Wu, Shuicai Wu, Po-Hsiang Tsui   +4 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source