Results 81 to 90 of about 926,881 (305)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Improved Density and Distribution Function Estimation
, 2018 Given additional distributional information in the form of moment restrictions, kernel density and distribution function estimators with implied generalised empirical likelihood probabilities as weights achieve a reduction in variance due to the ...
Oryshchenko, Vitaliy, Smith, Richard J.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Academy Journal of Science and Engineering, 2023 Climate and water resources are interconnected in a complex way such that a change in any one induces a change in another. Trend analysis is usually employed while assessing the long-term impact of climate variability on the environment, particularly ...
Nura Idris Abdullahi +4 more
doaj
Model Adequacy Checks for Discrete Choice Dynamic Models [PDF]
, 2012 This paper proposes new parametric model adequacy tests for possibly nonlinear and nonstationary time series models with noncontinuous data distribution, which is often the case in applied work.
Kheifets, Igor, Velasco, Carlos
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Applied Artificial Intelligence, 2018 In this paper, the parametric and non-parametric statistical tests are applied for comparisons of metaheuristic algorithms’ (MAs) behavior in solving Combined Economic Emission Dispatch (CEED) problem. In the last years, in many published papers, a large
Milena Jevtić +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Non-Parametric Goodness-of-Fit Tests Using Tsallis Entropy Measures
EntropyWe develop goodness-of-fit (GOF) procedures rooted in Tsallis entropy, with a particular emphasis on multivariate exponential-power (generalized Gaussian) and q-Gaussian models. The GOF statistic compares a closed-form Tsallis entropy under the null with
Mehmet Siddik Cadirci
doaj +1 more source
Basic statistical tools in research and data analysis
Indian Journal of Anaesthesia, 2016 Statistical methods involved in carrying out a study include planning, designing, collecting data, analysing, drawing meaningful interpretation and reporting of the research findings.
Zulfiqar Ali, S Bala Bhaskar
doaj +1 more source