Ektopično lučenje ACTH udruženo s hiperamilazemijom u bolesnika s karcinomom pluća malih stanica: prikaz slučaja [PDF]
Histologically confirmed small cell lung cancer associated with Cushing’s syndrome and elevated amylase is rarely described in the literature. We present a case of a 63-year-old patient admitted to cardiology department due to shortness of breath ...
Bojan Djokić +7 more
core +1 more source
Top‐Down Proteomics Study of Aging and Sexual Dimorphism of Zebrafish Brains
ABSTRACT Aging significantly impacts brain function and increases susceptibility to neurodegenerative diseases, with notable sex dimorphism observed in aging‐related dementia, such as Alzheimer's disease. To better understand the molecular mechanisms of aging and dementia, it is essential to globally and accurately characterize biomolecules (e.g ...
Mehrdad Falamarzi Askarani +6 more
wiley +1 more source
Glucagon Secreting Tumors and Glucagonoma Syndrome [PDF]
Glucagonomas are the functioning neuroendocrine tumors. These arise from pancreatic islet α-cells. These tumors are extremely rare and have an annual incidence of 1 per 20-40 million population 80% of glucagon-expressing tumors are sporadic, and 20% are ...
Bano, G +5 more
core
Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group. [PDF]
Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse ...
Abdallah, K. +80 more
core +2 more sources
A matter arising: When should inflammatory and autoimmune rheumatic diseases be considered ‘early’?
Timely recognition of inflammatory and autoimmune rheumatic diseases (IARDs) is important to optimize the early diagnosis with tailored interventions and possible prevention of irreversible organ damage. This narrative review provides an update by summarizing the advances in identifying the early stages of rheumatoid arthritis, systemic sclerosis and ...
Elvis Hysa +7 more
wiley +1 more source
Manifestações neurológicas como forma de apresentação do cancro do pulmão [PDF]
O cancro do pulmão, em particular o carcinoma de pequenas células do pulmão, é a principal causa maligna de síndromes paraneoplásicas. Esta revisão foca-se nos dados da literatura acerca da associação das síndromes paraneoplásicas com o cancro do pulmão.
Pereira, Maria Armanda Laureano Simões Castro
core +1 more source
Serum Ionized Calcium Variations in Simple and Comminuted Fractures in the Dog’s Appendicular Skeleton and Consequent Risks of a Hypercalcemic Condition [PDF]
A sample of 40 Canis familiaris (n=40) of unknown gender and breed was divided into two groups: (1) the control group (CG), which featured trauma but no fractures, and (2) the study group, which featured appendicular skeletal fractures (FG); FG was ...
Azevedo, Pedro +3 more
core +1 more source
AIRE's Complex Role Beyond Promiscuous Gene Expression
ABSTRACT Central tolerance, established in the thymus, ensures T cells are nonreactive to self‐antigens while maintaining a functional immune repertoire. Medullary thymic epithelial cells (mTECs) and thymic dendritic cells (DCs) play a crucial role in this mechanism by orchestrating the selection and deletion of autoreactive thymocytes, a process ...
Pärt Peterson
wiley +1 more source
The skin and internal disease : the importance of looking beyond the skin [PDF]
The skin is the largest organ in the human body. It has important 'local' roles such as protecting internal structures from potentially harmful factors in the environment but in addition is very much an integral part of the body and has a complex ...
Boffa, Michael
core
This study evaluated pituitary MRI results in cancer patients who experienced immune‐related hypophysitis while receiving immune checkpoint inhibitor treatment. MRI abnormalities were present in 63% of patients at follow‐up and 56% of patients at diagnosis, mostly in patients with multiple hormonal deficiencies.
Anna Angelousi +10 more
wiley +1 more source

