Results 91 to 100 of about 40,084 (217)

CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity

Glia, Volume 74, Issue 3, March 2026.
CDC42‐effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin‐dependent scaffolding of myelin. Myelin outfoldings do not cause secondary neuropathology per se. ABSTRACT The regular structure of CNS myelin requires specialized structural proteins, including septin ...
Sophie Hümmert, Joana Paes de Faria, Olaf Jahn, Ege Bilgin, Nikola Łukasik, Chethana Rao, Mišo Mitkovski, Fritz Benseler, Nils Brose, Sophie B. Siems, Sandra Goebbels, Wiebke Möbius, Helge Ewers, João B. Relvas, Hauke B. Werner   +14 more
wiley   +1 more source

Fisioterapia na recuperação funcional e qualidade de vida de cães paraplégicos por doença do disco intervertebral (Hansen tipo I) toracolombar submetidos à cirurgia descompressiva

Pesquisa Veterinária Brasileira
RESUMO: Este estudo retrospectivo incluiu cães paraplégicos com ausência de percepção a dor profunda secundário a doença do disco intervertebral toracolombar e submetidos à cirurgia descompressiva.
Amanda O. Andrades, Angel Ripplinger, Dênis A. Ferrarin, Graciane Aiello, Luciana Schneider, Marcelo L. Schwab, Alexandre Mazzanti   +6 more
doaj   +1 more source

Glycemic Variability as a Predictor of Mortality in Sepsis Patients With Concurrent Persistent Inflammation, Immunosuppression, and Catabolism Syndrome

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Background Sepsis is a life‐threatening condition caused by infection, which triggers dysregulated systemic inflammatory responses. Among sepsis patients, those who concurrently develop persistent inflammation, immunosuppression, and catabolism syndrome (PICS) have a significantly poorer prognosis.
Shuhang Wang, Li Liu, Bowen Li, Yancun Liu, Yanfen Chai   +4 more
wiley   +1 more source

Compression Paraplegia [PDF]

Proceedings of the Royal Society of Medicine, 1909
openaire   +2 more sources

Clinical Characteristics of Arginase 1 Deficiency: Natural History Insights From International Clinical Trials

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Arginase 1 deficiency (ARG1‐D) is an ultra‐rare inherited metabolic disorder of the urea cycle, caused by partial or complete loss of arginase 1 function, characterised by hyperargininaemia and a distinct, progressive neurological phenotype. The clinical development programme of pegzilarginase, a recombinant human ARG1 enzyme therapy, provides
Mattias Rudebeck, Nancy Braverman, Richard Chang, Gregory M. Enns, Arunabha Ghosh, Magali Gorce, Daniela Karall, Reena Sharma, Emily Shelkowitz, Roberto Zori, Markey McNutt   +10 more
wiley   +1 more source

Loss‐of‐Function Variants in CPT1C: No Support for a Causal Role in Hereditary Spastic Paraplegia

Movement Disorders, Volume 41, Issue 3, Page 779-784, March 2026.
Abstract Background Hereditary spastic paraplegias (HSPs) are neurodegenerative disorders characterized by lower‐limb spasticity. Pathogenic variants in CPT1C have been implicated in HSP. Objective The objective of this study was to assess whether CPT1C loss‐of‐function (LOF) variants are causally associated with HSP.
Rui Zhu, Lang Liu, Mehrdad A. Estiar, Farnaz Asayesh, Jamil Ahmad, Meron Teferra, Grace Yoon, Mark Tarnopolsky, Kym M. Boycott, Nicolas Dupre, Patrick A. Dion, Oksana Suchowersky, Albena Jordanova, Yi‐Chung Lee, Giovanni Stevanin, Stephan Zuchner, Guy A. Rouleau, Ziv Gan‐Or   +17 more
wiley   +1 more source

No Cystometrogram Among Veterans With Spinal Cord Injury Results in Adverse Urinary System Outcomes

Neurourology and Urodynamics, Volume 45, Issue 3, Page 494-502, March 2026.
ABSTRACT Background A prior study of a large cohort of veterans with supra‐sacral spinal cord injury or disorder (SCI/D) showed, as seen in other cohorts, substantial variation in application of bladder care processes and, specifically in the proportion of patients undergoing cystometrography (CMG). The next step in a systematic evaluation such as this
John Lavelle, John Hornberger
wiley   +1 more source

The endoplasmic reticulum in mitochondrial protein targeting: A neuronal perspective on organelle crosstalk

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Neurons depend on tightly regulated spatial proteostasis to maintain function across their extended morphology. The endoplasmic reticulum (ER), traditionally known for its function in protein synthesis, folding, and trafficking, has long been recognized as a central platform for directing proteins to organelles of the secretory and endocytic ...
J. Tabitha Hees, Angelika B. Harbauer
wiley   +1 more source

Breed Distribution of the Superoxide Dismutase 1 Gene Polymorphism Associated With Degenerative Myelopathy in a Canine Population From Different Geographical Regions of Türkiye

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
The SOD1:c.118G>A mutation associated with canine degenerative myelopathy was identified for the first time in the Kangal Shepherd, with an allele frequency of 0.057; it was also detected in the German Shepherd at a frequency of 0.140 and in the Toy Poodle at 0.089. The mutant allele frequency in the canine population in Türkiye has been estimated at 0.
Merve Yüksel, Kerem Ege, Ilayda Karakuş, Bilal Akyüz   +3 more
wiley   +1 more source

Critical Medical Ethics as an Approach to the Debate About Assisted Suicide by the Example of Germany

Bioethics, Volume 40, Issue 3, Page 324-332, March 2026.
ABSTRACT Recent literature has seen a growing endorsement of the so‐called autonomy‐only approach to assisted dying, which rejects suffering as a necessary criterion for access. Proponents argue that this model is most suitable to safeguard individuals against value‐based judgments of healthcare professionals about whether their lives are still worth ...
Meike Gerber
wiley   +1 more source