Results 91 to 100 of about 90,019 (314)

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

A pseudo‐homozygous missense variant and Alu‐mediated exon 5 deletion in FARS2 causing spastic paraplegia 77

Annals of Clinical and Translational Neurology
FARS2‐associated hereditary spastic paraplegia, later onset spastic paraplegia type 77, is a rarely neurodegenerative disease. Here, we reported two affected siblings in an autosomal recessive spastic paraplegia family with a pseudo‐homozygous missense ...
Shu‐Huai Lin, Jun‐Hao Xie, Jun‐Yi Jiang, Xin‐Yu Yan, Chao‐Yin Hong, Wan‐Jin Chen, Ning Wang, Xiang Lin   +7 more
doaj   +1 more source

FES rehabilitation platform with real-time control and performance feedback. [PDF]

, 2017
Osteoporosis after spinal cord injury is associated with low-trauma fractures, and consequently with increased risk of morbidity and mortality. The loss of bone mass density (BMD) due to paraplegia can be reduced through cyclical electrically-induced ...
Andrews, B., Armengol, M., Gibbons, R., Holderbaum, W., Poulton, A., Zoulias, I. D.   +5 more
core  

Microtubule-severing enzymes: From cellular functions to molecular mechanism. [PDF]

, 2018
Microtubule-severing enzymes generate internal breaks in microtubules. They are conserved in eukaryotes from ciliates to mammals, and their function is important in diverse cellular processes ranging from cilia biogenesis to cell division, phototropism ...
Ahmad, Akhmanova, Akhmanova, Allison, Antonina Roll-Mecak, Aubin-Tam, Banks, Barton, Benz, Bichet, Burk, Burk, Carlier, Carlier, Carlier, Charafeddine, Cheung, Chi, Connell, Denton, DeSantis, DesMarais, Dominguez, Dong, Doyle, Dymek, Dymek, Díaz-Valencia, Eckert, Evans, Francis J. McNally, Ganem, Gates, Grode, Guizetti, Han, Hara, Hartman, Hartman, Hawkins, Hazan, Hu, Hu, Iwaya, Jiang, Jiang, Jiang, Johjima, Joly, Kasher, Keating, Lacroix, Lata, Lee, Leo, Lindeboom, Liu, Loughlin, Lundin, Lučič, Maillard, Mains, Mao, Matsuo, McNally, McNally, McNally, McNally, McNally, McNally, Minoura, Mishra-Gorur, Mitchison, Monroe, Moretti, Mukherjee, Murata, Nakamura, Nicklas, Nithianantham, Olivares, Park, Peng, Portis, Puchades, Qiang, Rao, Reid, Rezabkova, Ribbeck, Rogers, Roll-Mecak, Roll-Mecak, Roll-Mecak, Roll-Mecak, Sharma, Sharp, Shaw, Sherwood, Sonbuchner, Srayko, Stamatakis, Stewart, Stone, Tao, Taylor, Ti, Tirnauer, Tran, Trotta, Vale, Valenstein, Vemu, Vemu, Vietri, Walker, Wang, Waterman-Storer, Wen, White, Whitehead, Wightman, Yang, Yang, Yang, Yu, Zehr, Zhang, Zhang, Zhang, Zhao   +130 more
core   +2 more sources

Mental Health and Corresponding Interventions for Persons With Physical Disabilities: A Scoping Review

Medicine Advances, EarlyView.
This scoping review of 33 studies maps the landscape of mental health in persons with physical disabilities. It finds a high prevalence of depression, anxiety, posttraumatic stress disorder, and other psychological problems, but highlights significant heterogeneity across studies in sample size, measurement, and representativeness.
Hui Li, Mengqian Li, Hongguang Chen, Xueting Bai, Qi Qiu, Nanqi Fan, Xin Wu, Xing Wang   +7 more
wiley   +1 more source

Feedback control of unsupported standing in paraplegia. Part I: optimal control approach [PDF]

, 1997
This is the first of a pair of papers which describe an investigation into the feasibility of providing artificial balance to paraplegics using electrical stimulation of the paralyzed muscles. By bracing the body above the shanks, only stimulation of the
Donaldson, N., Hunt, K.J., Munih, M.
core  

Wasting syndrome as a predictive factor for adverse health outcomes in older adults: A prospective cohort study

Nutrition in Clinical Practice, EarlyView.
Abstract Wasting syndrome (WS), also known as unintentional weight loss, is defined as a 5% reduction in body weight over a period of 6–12 months. The mortality associated with WS in older adults has not been adequately explored. The objective of this study was to investigate this relationship in hospitalized older individuals over an 18‐month period ...
Roana Carolina Bezerra dos Santos, Cláudia Porto Sabino Pinho, Eduila Maria Couto Santos, Maria Caroline da Silva Patricio, Stefany Beatriz do Nascimento, Letícia Sabino Santos, Taynara de Sousa Rego Mendes, Alcides da Silva Diniz   +7 more
wiley   +1 more source

Long-term case management and outcomes in a young male patient with complete paraplegia post T4-T5 vertebral osteomyelitis and a previous documented thalamo-mesencephalic hemorrhage – case presentation [PDF]

Balneo and PRM Research Journal
(1) Background: Vertebral osteomyelitis is an infection affecting the vertebrae, with a poten-tially devastating impact, which requires a prompt diagnosis established as quickly as possible to avoid complications such as neurological impairment ...
Roxana Bistriceanu, Aura Spînu, Cristina Daia, Ioana Andone, Cristina Popescu, Mihai Băilă, Ruxandra Postoiu, Gelu Onose   +7 more
doaj   +1 more source

Feedback control of unsupported standing [PDF]

, 1999
This paper presents the results of continuing work on feedback control of unsupported standing in paraplegia. Our experimental setup considers a situation in which all joints above the ankle are braced, and stabilising torque at the ankle is generated by
Donaldson, N., Gollee, H., Hunt, K.J., Jaime, R.   +3 more
core  

Embodying functionally relevant action sounds in patients with spinal cord injury [PDF]

, 2018
Growing evidence indicates that perceptual-motor codes may be associated with and influenced by actual bodily states. Following a spinal cord injury (SCI), for example, individuals exhibit reduced visual sensitivity to biological motion.
Galli, G., Giannini, Am, Lewis, J. W., Molinari, M., Pazzaglia, M., Scivoletto, G.   +5 more
core   +2 more sources