Results 141 to 150 of about 50,475 (278)

“Studio sull’efficacia della disostruzione bronchiale nelle persone con lesione midollare alta. Verifica di un programma riabilitativo con insufflazione ed essuflazione meccanica”

, 2005
In questo studio, un Trial clinico Randomizzato e Controllato, gli autori valutano l'efficacia dell'applicazione di uno strumento per la disostruzione bronchiale basato sull'alternanza di manovre di insufflazione ed essuflazione.
PILLASTRINI, PAOLO, BORDINI S., MENARINI, MAURO, BAZZOCCHI, GABRIELE, BARONCINI I., SALUCCI P., BELLONI G.   +6 more
core  

COVID‐19 as a Potential Trigger for Tuberculosis: Insights From a Large‐Scale Japanese Insurance Database Analysis

Journal of General and Family Medicine, Volume 27, Issue 4, July 2026.
In a nationwide propensity score–matched cohort study using Japanese insurance claims data, prior COVID‐19 was associated with a fourfold higher risk of subsequent active tuberculosis treatment initiation. The association was particularly pronounced among individuals with prior tuberculosis history.
Daisuke Miyamori, Kotaro Ikeda, Sachi Nagasaka, Masanori Ito   +3 more
wiley   +1 more source

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

Heterozygous OGDH Variants Are Involved in Peripheral Neuropathy With Ataxia and Optical Atrophy

JIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT 2‐oxyglutarate dehydrogenase (OGDH) encodes an E1 component of α‐ketoglutarate dehydrogenase complex that plays a pivotal role in the Krebs cycle. Biallelic variants in OGDH have been reported to cause an early‐onset neurodevelopmental and mitochondrial disorder.
Liedewei Van de Vondel, Gyu S. Lee, Jonathan De Winter, Satoshi Matsuzaki, Abigail Sandoval, Juan Felipe Ramirez, Alice Monticelli, Sukyeong Lee, Rita Horvath, Jan de Bleecker, Stephan Züchner, Kenneth M. Humphries, Jonathan Baets, Wan Hee Yoon   +13 more
wiley   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, Volume 46, Issue 4, Page 921-944, July 2026.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Hereditary Macular Degenerative Disease with Spastic Paraplegia

, 1963
Hereditary macular degenerative disease with Patient has spastic paraplegia associated with hereditary macular degenerative disease. Anatomy: Retina. Pathology: Cerebellar spinal degenerative disease.
William F. Hoyt, MD
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Structural Vulnerability in Health Research: A Systematic Mixed Studies Review

Journal of Advanced Nursing, Volume 82, Issue 7, Page 7104-7125, July 2026.
ABSTRACT Aims To systematically examine how structural vulnerability has been defined and operationalised in United States‐based health research, identify conceptual consistencies and methodological gaps, and propose core dimensions of structural vulnerability along with implications for future application in health research.
Levia A. Sutton, Carmen Alvarez, Therese S. Richmond, Sara F. Jacoby   +3 more
wiley   +1 more source

“Caratteristiche della funzione intestinale in una popolazione di mielolesi in fase post-acuta”

, 2005
Il 19-23% dei pazienti mielolesi necessita di almeno un'ospedalizzazione nella vita per disturbi correlati al tratto gastro-intestinale e la mortalità per patologie dle tratto alimentare è del 10%.
PILLASTRINI, PAOLO, ALMERIGI P. F., MENARINI, MAURO, BAZZOCCHI, GABRIELE, POLETTI E., BARONCINI I., SALUCCI P.   +6 more
core  

Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort

Annals of Neurology, Volume 99, Issue 6, Page 1363-1378, June 2026.
Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov, Ivana Dzinovic, Theresa Brunet, Vicente A. Yépez, Florian Hölzlwimmer, Elisabetta Indelicato, Birgit Assmann, Susann Badmann, Diana Ballhausen, Steffen Berweck, Felix Brechtmann, Melanie Brugger, Kevork Derderian, Felix Distelmaier, Philip Harrer, Denisa Harvanova, Petra Havrankova, Ann‐Kathrin Jaroszynski, Miriam Kolnikova, Robert Kopajtich, Anne Koy, Magdalena Krygier, Lukas Kunc, Katarina Kusikova, Oliver Maier, Maria Mazurkiewicz‐Bełdzińska, Christian Mertes, Ava Oberlack, Timo Roser, Alexandra Sitzberger, Ugo Sorrentino, Antonia M. Stehr, Katharina Vill, Matias Wagner, Holger Prokisch, Sylvia Boesch, Jan Necpal, Robert Jech, Juliane Winkelmann, Elisabeth Graf, Julien Gagneur, Matej Skorvanek, Michael Zech   +42 more
wiley   +1 more source

A meaning of well-being: from the experience of paraplegic Thai people

Journal of Health Science and Medical Research (JHSMR), 2008
The goal of care for paraplegic people is the enhancement of their "well-being". However, despite the frequent use of the term "well-being" its definition remains unclear and there is little information in the literature concerning the paraplegic's own ...
N Khupantavee, P Songwathana, A Chuaprapaisilp   +2 more
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