Results 171 to 180 of about 82,823 (261)
ART. III.—A CLINICAL AND THERAPEUTICAL CONTRIBUTION TO OUR KNOWLEDGE OF CERVICAL PARAPLEGIA [PDF]
, 1878 Edward Seguin
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Serious Neurologic Adverse Events in Tofersen Clinical Trials for Amyotrophic Lateral Sclerosis
Muscle &Nerve, Volume 71, Issue 6, Page 1006-1015, June 2025.ABSTRACT Introduction/Aims Tofersen is approved for the treatment of amyotrophic lateral sclerosis (ALS) due to superoxide dismutase 1 mutations (SOD1‐ALS). Here we report serious neurologic adverse events (AEs) that occurred in the tofersen clinical trials in people with SOD1‐ALS.
Alexandra Lovett +17 more
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European Journal of Neurology, Volume 32, Issue 6, June 2025.ABSTRACT Background Cortical hyperexcitability is an early feature of amyotrophic lateral sclerosis (ALS), linked to dysfunction in inhibitory and facilitatory cortical circuits, measurable using paired‐pulse transcranial magnetic stimulation (TMS). Short‐interval intracortical inhibition (SICI) is a robust biomarker of inhibitory function and an ALS ...
Cláudia Santos Silva +6 more
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ROTHERHAM HOSPITAL AND DISPENSARY. A CASE OF SYPHILITIC PARAPLEGIA; DEATH; NECROPSY; REMARKS [PDF]
, 1889 B WALKER
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Investigating the Association Between Companionship and Behavior Concordance: A Dyadic Panel Study
Personal Relationships, Volume 32, Issue 2, June 2025.ABSTRACT Partners in romantic relationships influence each other's behaviors through various social exchange processes. One underexplored process that is assumed to be relevant for couples' behaviors is companionship. Companionship is defined as experiencing pleasurable social interactions or engaging in shared activities for the purpose of having an ...
Patrick S. Höhener +4 more
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The Obstetrician &Gynaecologist, Volume 27, Issue 2, Page 115-121, April 2025.
Mohamed Shawky +3 more
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Loss of ADAP1/CentA1 Protects Against Autoimmune Demyelination
The FASEB Journal, Volume 39, Issue 9, 15 May 2025.ADAP1/CentA1 is an actin‐binding protein highly expressed in neurons. Our study describes a novel immunomodulatory function for ADAP1/CentA1 in the context of autoimmune demyelination. Mice lacking ADAP1/CentA1 were found partially resistant to the multiple sclerosis (MS) model experimental autoimmune encephalomyelitis (EAE) due to an altered ...
Jonathan J. Carver +6 more
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ChemBioChem, Volume 26, Issue 9, May 5, 2025.Regulated intramembrane proteolysis is crucial for functional proteome in all kingdoms of life. The task of cleaving transmembrane proteins within the unique environment of the lipid bilayer presents biochemical challenges that has been solved by integral membrane proteases (IMPRs).
Hannah Fremlén, Björn M. Burmann
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