Results 81 to 90 of about 690,789 (343)

Interorgan Molecular Communication Strategies of “Local” and “Systemic” Innate Immune Responses in Mosquito Anopheles stephensi

Frontiers in Immunology, 2018
Mosquitoes that transmit many deadly infectious diseases also need to keep fighting against many microbial infections. Constitutive expression of multiple antimicrobial peptides (AMPs) in almost all body tissues is believed to facilitate the effective ...
Tanwee Das De, Tanwee Das De, Punita Sharma, Tina Thomas, Deepak Singla, Sanjay Tevatiya, Seena Kumari, Charu Chauhan, Jyoti Rani, Vartika Srivastava, Ramandeep Kaur, Kailash C. Pandey, Rajnikant Dixit   +12 more
doaj   +1 more source

The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

Genome Biology, 2013
The small ruminant parasite Haemonchus contortus is the most widely used parasitic nematode in drug discovery, vaccine development and anthelmintic resistance research.
R. Laing, Taisei Kikuchi, Axel Martinelli, Isheng. J. Tsai, R. Beech, E. Redman, Nancy E. Holroyd, David J. Bartley, Helen Beasley, C. Britton, David Curran, Eileen Devaney, A. Gilabert, Martin Hunt, Frank Jackson, Stephanie L Johnston, Ivan Kryukov, Keyu Li, A. Morrison, A. Reid, N. Sargison, Gary I. Saunders, J. Wasmuth, Adrian Wolstenholme, M. Berriman, J. Gilleard, James A. Cotton   +26 more
semanticscholar   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Detection of the infective Plasmodium falciparum gametocytes by RT-qPCR assay from a malaria-endemic region of Northeastern India

Frontiers in Tropical Diseases
IntroductionThe diagnosis of infectious reservoirs in malaria (gametocytes) is necessary, especially in low-density infections and asymptomatic malaria patients. The gametocyte stage is a surrogate marker for infection of P. falciparum malaria in healthy
Ram Das, Kapil Vashisht, Lokesh Kori, Kuldeep Singh, Gaurav Kumar, Izazul Hasan, Jugal Gam, Kailash C. Pandey   +7 more
doaj   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Polymorphisms analysis of the Plasmodium ovale tryptophan-rich antigen gene (potra) from imported malaria cases in Henan Province

Malaria Journal, 2018
Background Plasmodium ovale has two different subspecies: P. ovale curtisi and P. ovale wallikeri, which may be distinguished by the gene potra encoding P. ovale tryptophan-rich antigen. The sequence and size of potra gene was variable between the two P.
Ruimin Zhou, Ying Liu, Suhua Li, Yuling Zhao, Fang Huang, Chengyun Yang, Dan Qian, Deling Lu, Yan Deng, Hongwei Zhang, Bianli Xu   +10 more
doaj   +1 more source

Composites of Shellac and Silver Nanowires as Flexible, Biobased, and Corrosion‐Resistant Transparent Conductive Electrodes

Advanced Functional Materials, EarlyView.
Shellac, a centuries‐old natural resin, is reimagined as a green material for flexible electronics. When combined with silver nanowires, shellac films deliver transparency, conductivity, and stability against humidity. These results position shellac as a sustainable alternative to synthetic polymers for transparent conductors in next‐generation ...
Rahaf Nafez Hussein, Tiago Carneiro Gomes, Eliza Ng, Simon Rondeau‐Gagné, Tricia Breen Carmichael   +4 more
wiley   +1 more source

African origin of the malaria parasite Plasmodium vivax

Nature Communications, 2014
Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes.
Weimin Liu, Yingying Li, Katharina S. Shaw, G. Learn, Lindsey J. Plenderleith, Jordan A. Malenke, Sesh A. Sundararaman, M. Ramírez, Patricia A. Crystal, Andrew G. Smith, F. Bibollet-Ruche, A. Ayouba, S. Locatelli, A. Esteban, Fatima Mouacha, E. Guichet, C. Butel, S. Ahuka-Mundeke, Bila‐Isia Inogwabini, Jean-Bosco N. Ndjango, Sheri Speede, C. Sanz, D. Morgan, M. K. Gonder, P. Kranzusch, P. Walsh, A. Georgiev, M. Muller, A. Piel, F. Stewart, M. Wilson, A. Pusey, L. Cui, Zenglei Wang, A. Färnert, C. Sutherland, D. Nolder, J. Hart, T. Hart, Paco Bertolani, Amethyst N. Gillis, M. Lebreton, Babila Tafon, John A. Kiyang, C. Djoko, B. S. Schneider, N. Wolfe, E. Mpoudi-Ngolé, E. Delaporte, R. Carter, R. Culleton, G. Shaw, J. Rayner, M. Peeters, B. Hahn, P. Sharp   +55 more
semanticscholar   +1 more source

CO2 Reduction on Copper‐Nitrogen‐Doped Carbon Catalysts Tuned by Pulsed Potential Electrolysis: Effect of Pulse Potential

Advanced Functional Materials, EarlyView.
This study demonstrates that pulsed potential electrolysis significantly improves CO2 reduction performance on copper‐nitrogen doped carbon electrodes. The formation of cationic copper sites and metallic clusters as a function of applied intermittent potential leads to notable selectivity changes compared to potentiostatic reduction.
Dorottya Hursán, Janis Timoshenko, Andrea Martini, Hyo Sang Jeon, Eduardo Ortega, Martina Rüscher, Arno Bergmann, Aram Yoon, Uta Hejral, Antonia Herzog, Clara Rettenmaier, Felix T. Haase, Philipp Grosse, Beatriz Roldan Cuenya   +13 more
wiley   +1 more source

Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection

Cellular Microbiology, 2014
Chronic Trypanosoma cruzi infections lead to cardiomyopathy in 20–30% of cases. A causal link between cardiac infection and pathology has been difficult to establish because of a lack of robust methods to detect scarce, focally distributed parasites ...
M. Lewis, Amanda Fortes Francisco, M. Taylor, Hollie Burrell-Saward, Alex P. McLatchie, M. Miles, J. Kelly   +6 more
semanticscholar   +1 more source