Results 31 to 40 of about 252,202 (262)

National Danish surveillance of invasive clinical Haemophilus influenzae isolates and their resistance profile

Frontiers in Microbiology, 2023
IntroductionThis study aimed to investigate the epidemiology, serotype distribution, phenotypical antibiogram, and molecular resistance gene characteristics of invasive Haemophilus influenzae infections in Denmark from 2014 to 2022.
Hans-Christian Slotved, Thor Bech Johannesen, Marc Stegger, Tine Dalby, Kurt Fuursted   +4 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Fitness estimates from experimental infections predict the long-term strain structure of a vector-borne pathogen in the field

Scientific Reports, 2017
The populations of many pathogen species consist of a collection of common and rare strains but the factors underlying this strain-specific variation in frequency are often unknown.
Jonas Durand, Maxime Jacquet, Olivier Rais, Lise Gern, Maarten J. Voordouw   +4 more
doaj   +1 more source

The influence of temperature and humidity on the flight activity of Culicoides imicola both under laboratory and field conditions

Parasites & Vectors, 2019
Background Insight into the factors that regulate the circadian host-seeking flight activity of Culicoides vectors (Diptera: Ceratopogonidae) will be of importance to assess the risk of transmission of Culicoides-borne pathogens.
Gert J. Venter, Solomon N. B. Boikanyo, Chantel J. de Beer   +2 more
doaj   +1 more source

Molecular characterization and epidemiology of Streptococcus pneumoniae serotype 8 in Denmark

BMC Infectious Diseases, 2021
Background Streptococcus pneumoniae serotype 8 incidence has increased in Denmark after the introduction of pneumococcal conjugated vaccines (PCV). The mechanism behind the serotype 8 replacement is not well understood. In this study, we aimed to present
Camilla Bülow Hansen, Kurt Fuursted, Palle Valentiner-Branth, Tine Dalby, Charlotte Sværke Jørgensen, H-C Slotved   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Validation of loop-mediated isothermal amplification for the detection of Loa loa infection in Chrysops spp in experimental and natural field conditions

Parasites & Vectors, 2021
Background The mass drug administration of ivermectin for onchocerciasis control has contributed to a significant drop in Loa loa microfilaria loads in humans that has, in turn, led to reduction of infection levels in Chrysops vectors.
Glory Ngongeh Amambo, Raphael Awah Abong, Fanny Fri Fombad, Abdel Jelil Njouendou, Franck Nietcho, Amuam Andrew Beng, Ritter Manuel, Mathias Eyong Esum, Kebede Deribe, Jerome Fru Cho, Peter Ivo Enyong, Catherine Poole, Achim Hoerauf, Clotilde Carlow, Samuel Wanji   +14 more
doaj   +1 more source

Experimental Evaluation of 100Cr6 Steel Microindented Surfaces Under Lubricated Nonconformal Point Contacts

Advanced Engineering Materials, EarlyView.
The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi, Pasquale Guglielmi, Gianfranco Palumbo, Giuseppe Carbone   +3 more
wiley   +1 more source

Handbook of Establishing and Maintaining Oxygen‐Free Atmospheres

Advanced Engineering Materials, EarlyView.
This study presents a practical framework for creating oxygen‐free atmospheres at ambient pressure using silane‐doped inert gases. The results show that ultra‐low oxygen levels and strongly reduced water content can be achieved through controlled silane dosing, drying systems, and sensor monitoring.
Sascha Jan Zimmermann, René Gustus, Lienhard Wegewitz, Wolfgang Maus‐Friedrichs   +3 more
wiley   +1 more source