Results 201 to 210 of about 9,472,164 (402)

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

open access: yesCytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas   +5 more
wiley   +1 more source

Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives

open access: yesChemMedChem, EarlyView.
Based on previously identified antimalarial agents, a series of highly substituted pyrazole and pyrimidines derivatives has been synthesized and tested for antiplasmodial and antileishmanial activity. Selected derivatives show promising antiplasmodial effect with a predicted favorable pharmacokinetic profile.
Matteo Lusardi   +7 more
wiley   +1 more source

Molecular iodine‐mediated functionalization of α‐Carbonyl Sulfoxonium ylides with Thiocyanates, Xanthates and Dithiocarbamates

open access: yesEuropean Journal of Organic Chemistry, Accepted Article.
In this work, we present a straightforward, rapid, and cost‐effective protocol for synthesizing three distinct classes of α‐functionalized sulfoxonium ylides—α‐xanthate, α‐thiocyanate, and α‐dithiocarbamate—via molecular iodine‐mediated reactions. This method demonstrates broad substrate tolerance, including heterocycles and steroids, delivering 25 ...
Kauê C. Capellaro   +1 more
wiley   +1 more source

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