Results 91 to 100 of about 257,672 (214)

TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain‐like behaviors in rats with neuropathic pain

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez   +7 more
wiley   +1 more source

Foot Biomechanics, Body Composition, and Sex‐Related Factors Associated With Work‐Related Musculoskeletal Discomfort in Standing Assembly‐Line Workers: A Cross‐Sectional Study

open access: yesJournal of Foot and Ankle Research, Volume 19, Issue 4, December 2026.
ABSTRACT Background Prolonged standing is common in manufacturing and assembly‐line work and is associated with musculoskeletal discomfort, especially in the lower limbs and spine. The influence of foot posture, morphology, and plantar loading patterns on this discomfort remains unclear.
Alejandro‐Jesús Almenar‐Arasanz   +7 more
wiley   +1 more source

Free‐Breathing Hepatic Oxygen Extraction Fraction (OEF) Mapping Using Radial GESSE

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 6, Page 2840-2847, December 2026.
ABSTRACT Purpose Noninvasive assessment of hepatic oxygenation is relevant for evaluating liver both in acute and long‐term liver pathologies. However, existing methods are limited to single‐slice acquisitions and require breath‐holding. This study aims to develop and evaluate a motion‐robust technique for whole‐liver oxygen extraction fraction (OEF ...
Ke Zhang   +9 more
wiley   +1 more source

Lower‐Limb‐Predominant Axonal Sensorimotor Polyneuropathy With Severe Proximal Weakness and Possible Myopathic Involvement After Sleeve Gastrectomy: A Case Report of Delayed Recognition

open access: yesClinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Bariatric surgery is increasingly performed in adolescents and young adults. Although sleeve gastrectomy preserves intestinal continuity and is often regarded as nutritionally low‐risk, it can still precipitate micronutrient deficiency, and obesity itself predisposes to thiamine deficiency, which can cause both Wernicke encephalopathy and a ...
Altin Kuqo, Floreta Kurti, Erand Llanaj
wiley   +1 more source

Automated assessment of paraspinal muscle fat composition based on the segmentation of chemical shift encoding-based water/fat-separated images

open access: yesEuropean Radiology Experimental, 2018
Proton-density fat fraction (PDFF) of the paraspinal muscles, derived from chemical shift encoding-based water-fat magnetic resonance imaging, has emerged as an important surrogate biomarker in individuals with intervertebral disc disease, osteoporosis ...
Thomas Baum   +8 more
doaj   +1 more source

Effect of Visualized Respiratory Training on Patient Cooperation and Image Quality in Gadoxetic Acid Disodium‐Enhanced Liver MRI: A Randomized Controlled Trial

open access: yesJournal of Magnetic Resonance Imaging, Volume 64, Issue 5, Page 1384-1395, November 2026.
ABSTRACT Background Respiratory motion artifacts impair diagnostic accuracy in gadoxetic acid disodium (Gd‐EOB‐DTPA)‐enhanced liver MRI. Conventional verbal pre‐scan breathing training often yields inconsistent patient cooperation and image quality, creating an urgent clinical need for optimized training methods.
Li Mei   +7 more
wiley   +1 more source

Electromyographic Study of Thoracic Paraspinal and Rectus Abdominis Muscles in Amyotrophic Lateral Sclerosis

open access: yes, 2018
Purpose: The aim of our study was the comparison of active denervation (fibrillation and/or positive sharp wave potentials) in thoracic paraspinal muscles with rectus abdominis in patients with definite amyotrophic lateral sclerosis. Methods: Ninety-five
Koutsoudaki, P.   +4 more
core   +1 more source

Predicting Clinical Improvement in Chronic Low Back Pain Using Exercise‐Induced IVIM Perfusion: Threshold Evaluation and Disability‐Dependent Effects

open access: yesNMR in Biomedicine, Volume 39, Issue 11, November 2026.
Previous findings showed that IVIM measures in lumbar muscles in response to acute exercise could predict response to exercise‐based rehabilitation in chronic low back pain. Here, we tested this in a larger independent cohort (n = 37), confirming greater increases in muscle diffusion (D) after exercise in those who responded to rehabilitation. However,
Frederique Dupuis   +8 more
wiley   +1 more source

Mind the gap: Reproducibility of methods for studying paraspinal muscles

open access: yes
Background: We respond to a recent study on Magnetic Resonance Imaging-based measurement of paraspinal muscles in patients with chronic back pain. Methods: We reviewed their methodology with a focus on segmentation tools and observer reliability. Results:
Nayia Aza   +2 more
core   +1 more source

Staged Lateral Lumbar Interbody Fusion Targeting Driver and Compensatory Structural Segments for Adult Degenerative Scoliosis: A Novel Strategy and Early Outcomes

open access: yesOrthopaedic Surgery, Volume 18, Issue 11, Page 2405-2416, November 2026.
Targeting driver and structural vertebrae via LLIF is an effective, minimally invasive strategy for ADS. It offers substantial deformity correction, symptom relief, and progressive postoperative self‐correction while significantly reducing surgical trauma compared to traditional long‐segment fusions.
Tianyong Wen   +7 more
wiley   +1 more source

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