Results 61 to 70 of about 541 (96)
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Journal of Medicinal Chemistry, 1983
Twenty-four structural derivatives of the antiarrhythmic drug changrolin were synthesized and tested for antiarrhythmic and parasympatholytic activities. It was found that while the bis(pyrrolidinylmethyl)phenol pattern of changrolin appeared to be optimal in this series, a wide latitude existed for the heteroaryl substituent for maintaining good ...
Barry S. Brown +4 more
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Twenty-four structural derivatives of the antiarrhythmic drug changrolin were synthesized and tested for antiarrhythmic and parasympatholytic activities. It was found that while the bis(pyrrolidinylmethyl)phenol pattern of changrolin appeared to be optimal in this series, a wide latitude existed for the heteroaryl substituent for maintaining good ...
Barry S. Brown +4 more
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Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates
Journal of Medicinal Chemistry, 1977The 38 esters in Table I were prepared from the four isomeric 2-tropanols and a variety of racemic glycolic acids and their optical isomers. Anticholinergic activity in mice was measured in the peripheral nervous system (mydriasis) and in the central nervous system (anti-tremorine) and compared with that of atropine, scopolamine, and racemic 2 ...
E R, Atkinson +7 more
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The American Journal of Digestive Diseases, 1952
Three patients known to suffer from glaucoma before Bentyl therapy apparently were free from altered intraocular pressure. Bentyl Hydrochloride is a new anticholinergic drug with a high degree of specificity for the gastrointestinal tract. In a series of 1,272 consecutive reported cases, including those receiving doses as high as 13 times the usual ...
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Three patients known to suffer from glaucoma before Bentyl therapy apparently were free from altered intraocular pressure. Bentyl Hydrochloride is a new anticholinergic drug with a high degree of specificity for the gastrointestinal tract. In a series of 1,272 consecutive reported cases, including those receiving doses as high as 13 times the usual ...
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Biochemical Pharmacology, 1976
Abstract The interactions of the parasympatholytics adiphenine, adiphenine H, propantheline and the structurally related compounds diphenhydramine, D -propoxyphene and methadone with acetylcholinesterases were studied by means of kinetic measurements.
Ulf-W. Wiegand +2 more
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Abstract The interactions of the parasympatholytics adiphenine, adiphenine H, propantheline and the structurally related compounds diphenhydramine, D -propoxyphene and methadone with acetylcholinesterases were studied by means of kinetic measurements.
Ulf-W. Wiegand +2 more
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Acta Medica Scandinavica, 1971
Abstract. Parasympatholytic treatment of bradyarrhythmias is part of the policy in coronary care units (CCU). Because of psychotic central nervous reactions following repeated i.v. doses of atropine, this drug was replaced by methyl scopolamine, and no such reactions have occurred since then.
L. Mogensen, E. Orinius
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Abstract. Parasympatholytic treatment of bradyarrhythmias is part of the policy in coronary care units (CCU). Because of psychotic central nervous reactions following repeated i.v. doses of atropine, this drug was replaced by methyl scopolamine, and no such reactions have occurred since then.
L. Mogensen, E. Orinius
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ChemInform, 1987
AbstractThe racemic hydrochloride of the title compound is an anticholinergic agent with an effect similar to that of atropine.
A. J. Aasen, L. Schjelderup
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AbstractThe racemic hydrochloride of the title compound is an anticholinergic agent with an effect similar to that of atropine.
A. J. Aasen, L. Schjelderup
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Investigations on the parasympatholytic effect of toxogonin on the guinea-pig isolated ileum
European Journal of Pharmacology, 1970Abstract 1. The parasympatholytic effect of toxogonin in the isolated guinea-pig ileum was investigated. Carbachol and arecaidine ethylester were used as cholinonimetics, N -methylatropine as a reference compound for competitive antagonism. 2. Toxogonin caused a parallel shift of the dose response curves of the agonists which was overproportional ...
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American Journal of Physiology-Heart and Circulatory Physiology, 1985
The direct effects of alinidine (N-allyl-clonidine) on the sinus node and atrioventricular (AV) junction were studied in 18 anesthetized dogs. Stimulus frequency-response curves to right stellate ganglion and right cervical vagus stimulations as well as responses to norepinephrine or acetylcholine were determined before and after selective perfusion ...
Gilbert R. Hageman +3 more
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The direct effects of alinidine (N-allyl-clonidine) on the sinus node and atrioventricular (AV) junction were studied in 18 anesthetized dogs. Stimulus frequency-response curves to right stellate ganglion and right cervical vagus stimulations as well as responses to norepinephrine or acetylcholine were determined before and after selective perfusion ...
Gilbert R. Hageman +3 more
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Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 2. Non-glycolates
Journal of Medicinal Chemistry, 1983The 19 esters in Table I were prepared from (+)-2 alpha-tropanol, (-)-2 beta-tropanol, (+/-)-3-quinuclidinol, and a variety of non-glycolic acids in order to compare their central and peripheral activities with those of the glycolates reported in the previous paper. The results (Table II) showed that esters 6 and 17 were approximately equivalent to one
E R, Atkinson +6 more
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Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui, 1990
The role of the vagus in bronchial asthma implicates to suggest that parasympatholytics are potent drugs in asthma therapy. The most important parasympatholytics today are ipratropium and oxitropium bromide. They are effective by blocking the cholinergic or muscarinic receptors of the bronchial smooth muscle and thereby inhibit cholinergic bronchomotor
D, Berdel, A V, Berg
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The role of the vagus in bronchial asthma implicates to suggest that parasympatholytics are potent drugs in asthma therapy. The most important parasympatholytics today are ipratropium and oxitropium bromide. They are effective by blocking the cholinergic or muscarinic receptors of the bronchial smooth muscle and thereby inhibit cholinergic bronchomotor
D, Berdel, A V, Berg
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