Results 1 to 10 of about 23,359 (99)
Best Practice & Research Clinical Endocrinology & Metabolism, 2018 Parathyroid carcinoma (PC) is a rare disease with an indolent behavior due to the low malignant potential. The etiology is unknown. Somatic mutations of CDC73 gene, the same gene involved in the hyperparathyroidism-jaw tumor syndrome, can be identified in up to 70% of patients with PC and in one-third of cases the mutations are germline.
Antonio Stefano, Salcuni +7 more
+9 more sources
Journal of Bone and Mineral Research, 2008 Parathyroid carcinoma is a rare endocrine tumour accounting for only about one of every hundred cases of primary hyperparathyroidism. The aetiology of this cancer remains obscure but the recent studies have identified that some gene mutations may be involved in its pathogenesis.
Marcocci, Claudio +5 more
+12 more sources
Current Treatment Options in Oncology, 2001 Although parathyroid neoplasms are common and cause primary hyperparathyroidism, parathyroid carcinoma is a rare entity. At times it can be difficult to diagnose. Patients with parathyroid carcinoma usually present with profound symptoms of hyperparathyroidism and highly elevated serum calcium and parathyroid hormone (PTH) levels.
A S, Khurana, M, Munjal, M, Narad
+9 more sources
British Journal of Surgery, 2005 Abstract Background Parathyroid carcinoma is a rare malignancy affecting 0·5–5 per cent of all patients with primary hyperparathyroidism. This article reviews the literature on the pathogenesis, pathology, clinical features, diagnosis and management of parathyroid carcinoma.
N, Rawat +3 more
+7 more sources
Current Opinion in Oncology, 2006 This article reviews current knowledge on the etiology, diagnosis and treatment of parathyroid carcinoma.Due to its rarity, research on the molecular etiology and treatment of parathyroid carcinoma has been slow. Mutations of the tumor suppressor gene, HRPT2, and resultant loss of expression of its gene product have been found in the majority of ...
Steven E, Rodgers, Nancy D, Perrier
+9 more sources
BJS (British Journal of Surgery), EarlyView., 2020 This study investigated postoperative complications after surgery for medullary thyroid carcinoma (MTC) in Europe. Hypoparathyroidism, recurrent laryngeal nerve palsy and bleeding requiring reoperation occurred in 170 (26·2 per cent), 62 (13·7 per cent) and 17 (2·6 per cent) patients respectively.
D.‐J. van Beek +18 more
wiley +1 more source
Journal of the Belgian Society of Radiology, 2013 Background: A 32-year-old woman with palpable neck mass and clinical presentation of hypercalcemic crisis and primary hyperparathyroidism was referred to radiology and nuclear medicine departments for imaging studies.
A, Dilli +3 more
+9 more sources
Otolaryngologic Clinics of North America, 2010 Parathyroid carcinoma is a rare tumor that is prone to recurrence and poor local-regional control. Despite advances in technologies that have shown promise for accurate diagnosis, the mainstay of initial diagnosis remains pathologic analysis and clinical assessment.
W Cross, Dudney +2 more
openaire +4 more sources
Giant Parathyroid Tumor: Parathyroid Adenoma versus Parathyroid Carcinoma
Case Reports in Endocrinology, 2022 Parathyroid adenoma is the most common cause of primary hyperparathyroidism (PHPT). We present the preoperative detection of a giant parathyroid adenoma (GPA) using (99mTc)-sestamibi parathyroid scintigraphy in a patient presenting with severely elevated parathyroid hormone, hypercalcemia, hypophosphatemia, and vitamin D insufficiency.
Farid Gossili +3 more
openaire +4 more sources
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source