Does Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN) of the Parathyroid Gland Exist? First Description of a Possible Case [PDF]
Head and Neck Pathology, 2020 We describe the histological, histochemical, and immunohistochemical features of an unusual neoplasm of the parathyroid gland showing the histologic criteria of a mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN). To the best of our knowledge, this
Silvana Di Palma +4 more
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Genetic and Epigenetic Alterations in Parathyroid Neoplasms [PDF]
Iranian Journal of Pathology, 2022 The exact etiology of parathyroid carcinomas (PC) is still unknown. Their associations have with several inherited syndromes or specific genetic lesions have been established. The management of PC is challenging for clinicians. The complexity of molecular phenotypes increases with tumor aggressiveness.
Seyed Amir Miratashi Yazdi, Elham Nazar
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Intranuclear holes (cytoplasmic pseudoinclusions) in parathyroid neoplasms, or “holes happen” [PDF]
Cancer, 2000 A parathyroid adenoma demonstrating intranuclear holes on aspiration cytology prompted a review of parathyroid neoplasms to determine the frequency of this phenomenon.Aspiration cytology slides from 30 parathyroid adenomas and 1 parathyroid carcinoma were reviewed.
John R. Goellner, Jill L. Caudill
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Synchronous Parathyroid Carcinoma and Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features [PDF]
Cureus, 2022 Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Compared to parathyroid adenoma, parathyroid cancer is more likely to be associated with marked levels of serum parathyroid hormone (PTH) and hypercalcemia with severe clinical ...
Ahmed N Alajaimi +3 more
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IMMUNOCHEMICAL IDENTIFICATION OF PARATHYROID HORMONE IN NON-PARATHYROID NEOPLASMS ASSOCIATED WITH HYPERCALCEMIA [PDF]
The Journal of Experimental Medicine, 1964 1. Immunochemical cross-reactivity, but not identity, has been demonstrated between bovine parathyroid hormone and an antigen in biologically active extracts of human parathyroid tissue by quantitative C' fixation and C' fixation inhibition. 2.
Armen H. Tashjian +2 more
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Clinical and molecular genetics of parathyroid neoplasms [PDF]
Best Practice & Research Clinical Endocrinology & Metabolism, 2010 Primary hyperparathyroidism (HPT) results from the excessive secretion of parathyroid hormone from parathyroid tumours. While most HPT is sporadic, it is associated with a familial syndrome in a minority of cases. The study of these syndromes has helped define the pathophysiology of both familial and sporadic parathyroid neoplasms.
John M. Sharretts, William F. Simonds
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Parathyroid carcinoma an unusual endocrine neoplasm: current review
International Journal of Research in Medical Sciences, 2023 Parathyroid carcinoma is an unusual endocrine neoplasm, in practice, diagnosis and clinical approach is challenging, it could be suspected during pre-surgical approach or in the same surgical procedure, however most of the cases get the diagnosis with ...
Edgar A. Reyes-Velázquez
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Parathyroid Retrospective Analysis of Neoplasms Incidence (pTRANI Study): An Italian Multicenter Study on Parathyroid Carcinoma and Atypical Parathyroid Tumour [PDF]
Journal of Clinical Medicine, 2023 Background: Parathyroid cancer (PC) is a rare sporadic or hereditary malignancy whose histologic features were redefined with the 2022 WHO classification. A total of 24 Italian institutions designed this multicenter study to specify PC incidence, describe its clinical, functional, and imaging characteristics and improve its differentiation from the ...
Angela Gurrado +44 more
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Novel PRUNE2 Germline Mutations in Aggressive and Benign Parathyroid Neoplasms [PDF]
Cancers, 2023 Parathyroid tumors are mostly sporadic but can also occur in familial forms, including different kinds of genetic syndromes with varying phenotypes and penetrance. Recently, somatic mutations of the tumor suppressor gene PRUNE2 were found to be frequent in parathyroid cancer (PC).
Sara Storvall +3 more
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Parathyroid Neoplasms: The Army Hospital (Research & Referral) Experience [PDF]
Medical Journal Armed Forces India, 2006 Neoplasms of the parathyroid are common but parathyroid carcinoma is exceptionally rare. In contrast to most other malignant endocrine tumours that are usually less hormonally active, malignant parathyroid tumours are hyper functional. Malignant parathyroid tumours pose a diagnostic dilemma for the pathologist.To study the clinicopathological profile ...
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