Results 231 to 240 of about 420,147 (288)
Chemistry – A European Journal, EarlyView.ABSTRACT ROS production due to Cu(amyloid‐β) redox cycling is proposed to contribute to the oxidative stress observed in Alzheimer's disease brains. We previously reported on a nitrogen and sulfur‐containing ligand, L, able to arrest Cu(Aβ)‐induced ROS production [Chem. Eur. J. 2023, 29,].
Marielle Drommi +4 more
wiley +1 more source
Catalytic Amyloids: Turning Fibrils Into Biocatalysts
Chemistry – A European Journal, EarlyView.Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito +3 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran +4 more
wiley +1 more source
The Need for Research on Counseling Interventions for Children and Adolescents from Divorced Families: A Literature Review [PDF]
, 2008 Gutzwiller, Michael
core +1 more source
Ambident Reactivity in the Phenyl + NO Radical Recombination
Chemistry – A European Journal, EarlyView.ABSTRACT The recombination reaction of nitric oxide (NO) with radicals via its oxygen atom, rather than the more common nitrogen site, offers an intriguing pathway to the formation of oxynitrenes. The photochemical isomerization of nitroso compounds into their corresponding oxynitrenes may involve such a step.
Virinder Bhagat +3 more
wiley +1 more source
Annals of the Child Neurology Society, EarlyView.ABSTRACT Objective Autism spectrum disorder (ASD) affects 1 in 36 individuals in the United States and is characterized by impaired social communication and restrictive/repetitive behaviors. Individuals with tuberous sclerosis complex (TSC) have a high incidence of ASD (40%) and exhibit congenital brain lesions (tubers), offering a unique lesion‐based ...
Wendy Xiao Herman +10 more
wiley +1 more source
An evaluation of the need and early intervention support for children (aged 2-4 years) with an autistic spectrum disorder in Northern Ireland [PDF]
, 2007 Cassidy, Arlene +2 more
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Clinical Pharmacology in Drug Development, EarlyView.Abstract Mocravimod, a novel immunomodulator targeting sphingosine‐1‐phosphate receptor (S1PR), is being developed as a maintenance treatment for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. Preclinical data suggested that cytochrome (CYP) 3A4 is the primary enzyme involved in mocravimod metabolism.
Dymphy R. Huntjens +2 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Baloxavir acid (baloxavir), the active metabolite of the prodrug baloxavir marboxil, is a selective inhibitor of the influenza virus cap‐dependent endonuclease. The population pharmacokinetic (popPK) profile of baloxavir in adults/adolescents has been described previously.
Sylvie Retout +6 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maud Maillard +18 more
wiley +1 more source