Results 81 to 90 of about 230,879 (259)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Parent-Child Interaction Therapy in a Case of Global Developmental Delay and Leukoencephalopathy

Frontiers in Psychiatry, 2018
Parent-child interaction therapy (PCIT) is an evidence-based, behavioral dyadic treatment for caregivers and their children aged 2–7 years old with emotional and behavioral disorders.
Reem M.A. Shafi, Jennifer L. Vande Voort, Paul E. Croarkin, Magdalena Romanowicz   +3 more
doaj   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Cooperative parent mediated therapy for Italian children with autism spectrum disorder: a clinical experimental study in a community healthcare service in Italy

Frontiers in Child and Adolescent Psychiatry
IntroductionThis Clinical Experimental Study aimed to evaluate the effectiveness of Cooperative Parent Mediated therapy (CPMT), a targeted parent-coaching program for Autism Spectrum Disorder (ASD), in Community Healthcare Service in Italy.MethodsForty ...
Alessandra Carta, Laura Casula, Salvatorica Manca, Mariangela Valentina Puci, Giuseppina Puseddu, Giuseppina Puseddu, Elisa Fucà, Giovanni Sotgiu, Stefano Vicari, Stefano Vicari, Stefano Sotgiu, Giovanni Valeri   +11 more
doaj   +1 more source

Проблема оптимизации детско-родительских взаимоотношений в неполной семье [PDF]

, 2018
THE PROBLEM OF OPTIMIZATION OF CHILD-PARENTAL RELATIONS IN THE INCOMPLETE FAMILY E. KOVALEVA, I. SULIMAРассматривается проблема изучения детско-родительских взаимоотношений в неполной семье. Представлена актуальность исследования, которая определяется,
Ковалёва, Е. А., Сулима, И. В.   +1 more
core   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

The effect of parent and child interaction therapy focused emotional on parent\'s reactions to children negative emotions in children with depression

مجله علوم روانشناختی, 2022
Background: Several studies have been conducted on the effectiveness of parent-child interaction therapy on internalized disorders in children. However, no study has been conducted on the effectiveness of emotion-based parent-child interaction therapy on
Azimeh Alsadat Fatemi, Mosaieb Yarmohamadi, Hossain Mohagheghi, Mohammadreza Zoghipaidar   +3 more
doaj  

Development of a Barriers Scale to Predict Early Treatment Success for Young Children in Poverty with Behavior Problems [PDF]

, 2016
Research has demonstrated that participation in parent and child therapy (PCT) programs significantly reduces problematic behaviors while increasing positive behaviors in the child.
Besasie, Lauryn A., Fox, Robert A., Gresl, Brittany Lynn   +2 more
core   +1 more source

Towards understanding the child’s experience in the process of parentification: young adults’ reflections on growing up with a depressed parent [PDF]

, 2014
This article reports on a qualitative study with 21 young adults who grew up with a depressed parent. We examined how young adults make sense of their childhood experiences of parental depression and how their retrospective reflections help us to ...
Bonnewyn, Anke, De Mol, Jan, Hooghe, An, Rober, Peter, Van Parys, Hanna   +4 more
core   +2 more sources