Advanced Science, EarlyView.Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang +14 more
wiley +1 more source
Parent-child agreement in reporting somatic distress, gastrointestinal symptoms, mental health, and general health in girls with functional abdominal pain. [PDF]
Eur J PediatrDuberg A, Eriksson M, Philipson A.
europepmc +1 more source
A Quest for the Mechanism of Ultrahigh Resolution SEM Imaging
Advanced Science, EarlyView.Using Monte Carlo simulations with explicit definitions of SE1 and SE2 align with a cascade secondary electron production model, this work shows that the 3D nanostructure modulated SE2 emission enhances other than to reduce topographical contrast via a “miniature Faraday cup” effect.
Hao Tian Chen +3 more
wiley +1 more source
Parent-child shared book reading challenges and facilitators: a systematic review and meta synthesis. [PDF]
Front PsycholNan J, Tian Y.
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao +14 more
wiley +1 more source
Associations Between Parent-Child Attachment and Psychosocial- and Health-Related Symptoms in Children with Functional Abdominal Pain Disorders. [PDF]
Children (Basel)Matherne CE +5 more
europepmc +1 more source
Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing
Advanced Science, EarlyView.CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen +15 more
wiley +1 more source
Longitudinal effects of school boarding on adolescent depression: examining the mediating role of parent-child closeness and school connectedness. [PDF]
BMC PsycholLeng LL, Dayimu N.
europepmc +1 more source
Advanced Science, EarlyView.This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang +11 more
wiley +1 more source
The relationship between family physical activity environment and mental health in high school students: the chain mediating role of parent-child relationship and exercise behavior. [PDF]
Front Public HealthFeng X, Xu E.
europepmc +1 more source