Results 81 to 90 of about 2,859,394 (254)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Parents' work-family conflict and parent‒child relationship: The mediating role of parenting burnout and the moderating role of self-compassion.

PLoS ONE
In today's fast-paced society, balancing work and family has become a key challenge affecting individual well-being, particularly for working parents.
Jing Liang, Zongping Chen
doaj   +1 more source

When There’s Conflict:Interparental Conflict, Parent-Child Conflict, and Youth Problem Behaviors

, 2008
This study examined direct and indirect associations between overt and covert interparental conflict (IPC), parent—child conflict, and their links to youth problem behaviors. Data were collected from a sample of 641 school-age youth, ages 12 to 18 years,
Vaughn, L, Barber, B K, Brian K. Barber, LaToya Burns Vaughn, Bradford, Kay, Kay Bradford   +5 more
core   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

The impact of lockdown on child adjustment: a propensity score matched analysis

BMC Psychology
The COVID-19 pandemic has had an inestimable impact worldwide, challenging the daily lives and interactions of children and their families. In 2022, Shanghai implemented a three-month lockdown in response to an acceleration of positive cases during the ...
Wanjuan Weng, Mowei Liu, Shumin Wang, Xiaoyun Li, Jinghui Zhang, Yuke Fu, Chuanmei Dong, Yan Li   +7 more
doaj   +1 more source

Risk factors in child maltreatment: a meta-analytic review of the literature [PDF]

, 2009
This review presents the results of a series of meta-analyses identifying the relative strength of various risk factors for child physical abuse and neglect. Data from 155 studies examining 39 different risk factors were included in the review.
Boykin, Esther L., Harris, Jennifer M., Stith, Sandra M., Davies, L. Christopher, Dees, J. E. M. E. G., Som, Anurag, Alder, Meagan C., McPherson, Mary, Liu, Ting   +8 more
core  

Threat is a Multidimensional Construct: Exploring the Role of Children's Threat Appraisals in the Relationship Between Interparental Conflict and Child Adjustment

, 2009
Past research has emphasised the importance of children's appraisals of the threat posed by parent conflict for understanding links between interparental conflict and child outcomes.
Chipuer, Heather, Atkinson, Erin R., Dadds, Mark R, Atkinson, Erin R, Dadds, Mark R., Dawe, Sharon   +5 more
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source