Results 51 to 60 of about 630,730 (284)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The Role of the Community Nurse in Promoting Health and Human Dignity-Narrative Review Article.
Iranian Journal of Public Health, 2013 Population health, as defined by WHO in its constitution, is out "a physical, mental and social complete wellbeing". At the basis of human welfare is the human dignity. This dimension requires an integrated vision of health care. The ecosystemical vision
Ana Muntean +2 more
doaj
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Frontiers in Pediatrics, 2021 Objective: The aim of this study was to examine the association between parenting, including the parent–child interaction and child maltreatment in the first grade (6–7 years old), and school refusal in the second (7–8 years old) and fourth (9–10 years ...
Yoshifumi Fukuya +4 more
doaj +1 more source
The importance of early parenting for later child outcomes: A study with Spanish families with children with disabilities [PDF]
, 2018 Children with different disability conditions have varied developmental trajectories, which perhaps influences parent-child interaction. For these and all infants, an optimal home environment that includes good parenting and positive parent-child ...
Bersabe-Moran, Rosa Maria +6 more
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Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Humanities & Social Sciences CommunicationsPlayfulness plays a pivotal role in fostering individual development across cognitive, emotional, and creative domains. This study aims to investigate parental playfulness and playfulness among 681 Chinese children aged 3–6 years, including 356 boys (52 ...
Yonggang Wei +4 more
doaj +1 more source
Brief report: a comparison of child mental health inequalities in three UK population cohorts [PDF]
, 2019 There are substantial health disparities between children from low and higher income families. The study aimed to test changes in child mental health inequalities across three large UK population cohorts of 11-year old children assessed in 1999, 2004 and
Collishaw, Stephan +3 more
core +3 more sources
Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund +3 more
wiley +1 more source
Child–parent interaction in relation to road safety education : Part 2 – main report [PDF]
, 2008 • Children and young people are particularly vulnerable road users. • Child pedestrian injury rates are poor compared with the rest of Europe. • The factors that impact on children’s road safety and their capability in traffic are numerous, multi-faceted
Ayrton, Rebecca +6 more
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