Results 41 to 50 of about 230,967 (299)

Systematic review of interventions for the secondary prevention and treatment of emotional abuse of children by primary carers [PDF]

, 2008
Background Emotional abuse (or psychological maltreatment, as it is more commonly called in the US) is an inadequately researched and poorly understood concept, despite increasing awareness about the harm it can cause to children‟s lives.
Barlow, Jane, Carter, Yvonne, McMillan, Anita Schrader, Paul, Moli, Sidebotham, Peter, Stewart-Brown, Sarah L.   +5 more
core  

Treatment Outcomes for Toddlers with Behaviour Problems from Families in Poverty [PDF]

, 2009
Background. Relatively few treatment studies address mental health issues in very young children. This study examined the effectiveness of a treatment program for toddlers whose behavior problems were further complicated by living in poverty. Method.
American Psychiatric Association, Bagner, Baker, Baker, Behan, Brenner, Campbell, Campbell, Crawley, Einfeld, Eyberg, Eyberg, Eyberg, Feldman, Fox, Fox, Fox, Fox, Gavidia-Payne, Greene, Hofstra, Holtz, Huaqing Qi, Kaufman, McIntyre, Mendez, Nicholson, Nicholson, Nix, Nock, Patterson, Reid, Roberts, Roberts, Sanders, Sigafoos, Snell-Johns, US Department of Education, Webster-Stratton, Weis   +39 more
core   +2 more sources

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

One-year follow-up of family versus child CBT for anxiety disorders: Exploring the roles of child age and parental intrusiveness. [PDF]

, 2009
ObjectiveTo compare the relative long-term benefit of family-focused cognitive behavioral therapy (FCBT) and child-focused cognitive behavioral therapy (CCBT) for child anxiety disorders at a 1-year follow-up.MethodThirty-five children (6-13 years old ...
McLeod, Bryce D, Piacentini, John C, Sigman, Marian, Wood, Jeffrey J   +3 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Проблема оптимизации детско-родительских взаимоотношений в неполной семье [PDF]

, 2018
THE PROBLEM OF OPTIMIZATION OF CHILD-PARENTAL RELATIONS IN THE INCOMPLETE FAMILY E. KOVALEVA, I. SULIMAРассматривается проблема изучения детско-родительских взаимоотношений в неполной семье. Представлена актуальность исследования, которая определяется,
Ковалёва, Е. А., Сулима, И. В.   +1 more
core   +1 more source

A randomized clinical trial comparing family-focused treatment and individual supportive therapy for depression in childhood and early adolescence [PDF]

, 2017
OBJECTIVE: Despite the morbidity and negative outcomes associated with early-onset depression, few studies have examined the efficacy of psychosocial treatment for depressive disorders during childhood.
Asarnow, Joan R., Langer, David A., Sugar, Catherine A., Tompson, Martha C.   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Telehealth for expanding the reach of early autism training to parents. [PDF]

, 2012
Although there is consensus that parents should be involved in interventions designed for young children with autism spectrum disorder (ASD), parent participation alone does not ensure consistent, generalized gains in children's development.
Rogers, Sally J, Vismara, Laurie A, Young, Gregory S   +2 more
core   +3 more sources