Results 71 to 80 of about 31,578 (255)

Review on Neonatal End-of-Life Decision-Making: Medical Authority or Parental Autonomy?

Proceedings of Singapore Healthcare, 2013
As advances in medical technology are constantly re-defining the lower limit of newborn viability, the practice of withholding/withdrawing treatment in neonatal care is increasingly prevalent.
Tu Anh Pham Nguyen BSc, Lai Yun Ho FAMS, FRCPCH   +1 more
doaj   +1 more source

Roditeljski autoritet u odnosima između roditelja i adolescenata

Društvena istraživanja : časopis za opća društvena pitanja, 2010
Mit dieser Studie soll untersucht werden, auf welche Weise sich Eltern (auf dem Wege der Kommunikation) ihren adoleszenten Kindern gegenüber behaupten, zumal in Situationen, die die elterliche Autorität gefährden. Es sollen die wahrscheinlichsten Verlaufsweisen „brenzliger“ Situationen ins Auge gefasst werden, ferner ideale Verlaufsweisen sowie die ...
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Chastisement of minors as a means of educational influence

Journal of Modern Science
Objectives To present the role of parents in the process of responsible child-rearing in the context of the chastisement of minors as an educational method of upbringing that isn’t legally indeifferent and state policy towards chastisement of upbringing
Wojciech Lis
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

SUBSTITUTION OF PARENTAL CONSENT WHEN MINORS TRAVEL ABROAD: SANCTION OR REMEDY? [PDF]

Challenges of the Knowledge Society, 2019
Decisions on establishment of minors' place of residence fall within the sphere of application of joint parental authority, along with decisions concerning the form of education and professional training, complex medical treatments and surgical ...
Anca Magda VOICULESCU
doaj  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Religious Education of the Child as Part of Parental Duties – Comparative Legal Analysis of National Reports Submitted to the Commission on European Family Law

Multidisciplinary Journal of School Education
Research objectives and problems: This article presents a comparative analysis of legal regulations in 21 European countries regarding parents’ rights and obligations towards their children’s religious education and upbringing.
Marta Prucnal-Wójcik
doaj