Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Cohabiting unions in France and West Germany: transitions to first birth and first marriage [PDF]
This paper compares the non-marital birth pattern in France and West Germany. Since the beginning of the eighties, France witnessed a steady increase in non-marital birth rates, while in West Germany non-marital birth rates have remained at a relatively ...
Jean-Marie Le Goff
core
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Parental Authority Regarding the Minor’s Person in the Regulation of the French Civil Code [PDF]
In the French Civil Code, the parental authority regarding the minor’s person is defined as a set of rights and obligations whose exercise and fulfilment concerns the minor’s interest (art. 371-1 par. 1 of the French Civil Code).
Gavrilescu, Alin-Gheorghe
core
Who Owns the Soul of the Child?: An Essay on Religious Parenting Rights and the Enfranchisement of the Child [PDF]
, 2012 At common law, and (for most of the nation\u27s history) under state statutory regimes, the authority of the parent to direct the child\u27s upbringing was a matter of duty, not right, and chief among parental obligations was the duty to provide the ...
Shulman, Jeffrey
core +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Effectiveness of the Coping Power program on Family Problem Solving, Parental Authority, Social Information Processing, and Emotional Awareness of Maladjusted Children Aged 9-13 [PDF]
Taḥqīqāt-i ̒Ulūm-i RaftārīAim and Background: Children and teenagers are of a particular importance in every society, and a care for their mental health makes them healthy both mentally and physically, and enable them to play their social parts better in the future.
Maedeh Faramarzi, Mansoreh Bahramipour
doaj
The family drug & alcohol court (FDAC) evaluation project [PDF]
, 2011 This report presents the findings from the evaluation of the first pilot Family Drug and Alcohol Court (FDAC) in Britain. FDAC is a new approach to care proceedings, in cases where parental substance misuse is a key element in the local authority ...
Alrouh, B +6 more
core
Grandparents and contact: 'rights v welfare' revisited [PDF]
, 2001 This article examines the legal position of members of the extended family involved in contact (access) disputes and locates the discussion within the debate about the utility of rights in resolving such disputes. In particular it focuses on Article 8 of
Kaganas, F, Piper, CD
core +1 more source
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source