Results 131 to 140 of about 585,089 (288)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Testing the impact on educational achievement of expectations [PDF]
, 2016 Parental and students’ expectations on the educational achievement of the latter have been highlighted in the literature as proper proxies for students’ forthcoming performance and high school track elections.
Lopez-Agudo, Luis Alejandro +1 more
core
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
Female Labor Force Participation in Asia: Key Trends, Constraints, and Opportunities [PDF]
, 2016 Key Messages In Asia, female labor force participation ranges from 16% in Afghanistan to 83% in Nepal, while male labor force participation ranges from 52% in Timor-Leste to 89% in Nepal.
Muzones, Maricor, Tanaka, Sakiko
core +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
BMC PediatricsBackground Encouraging children to participate in organized sports could increase physical activity and may promote lifelong healthy habits. There are socioeconomic disparities in organized sports participation in school-aged children and adolescents ...
Charlotte Wilén +8 more
doaj +1 more source
State of the World's Fathers: 2015 [PDF]
, 2015 Fathers' involvement in their children's lives has been linked to higher cognitive development and school achievement, better mental health for boys and girls, and lower rates of delinquency in sons. Studies in multiple countries have shown that fathers'
Gary Barker +4 more
core
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Does internal parental migration affect child school participation and work in Indonesia?
Cogent Social SciencesThis study aims to analyse how internal parental migration influences school participation and work for children aged 10–15 years in Indonesia as measured by four categories, namely, (a) children attending school, (b) working children, (c) children ...
Susilo +3 more
doaj +1 more source