Results 81 to 90 of about 863,294 (293)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Intergenerational Transfers and Household Structure. Why Do Most Italian Youths Live With Their Parents? [PDF]

open access: yes
85 percent of Italian men aged 18-33 live with their parents. We argue that Italian parents like to live with their children and a rise in their income makes it possible for them to offer their children higher consumption in exchange for their presence ...
Enrico Moretti, Marco Manacorda
core  

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Impact of Child Labour on School Attendance and School Attainment: Evidence from Bangladesh [PDF]

open access: yes
The paper examines the linkages between child work and both school attendance and school attainment of children aged 5–17 years using data from a survey based in rural Bangladesh.
Khanam, Rasheda, Ross, Russell
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Feinfühligkeit, Selbstverstrauen, Orientierung: Erfahrungen und Reflexionen zur elterlichen Kompetenz in der Spätmoderne aus der Sicht der Erziehungsberatung

open access: yesEuropean Journal of Mental Health, 2015
Empathy, Self-Confidence, Orientation: Parental Competence in Late Modernity from the Perspective of Educational Counselling in Germany: Experiences and Reflections: As an easily accessible service of youth and family protection, educational counselling ...
Maria Bushuven   +2 more
doaj  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

The effect of parental rearing conditions on offspring life history in Anopheles stephensi

open access: yesMalaria Journal, 2007
Background The environmental conditions experienced by parents are increasingly recognized to impact the success of offspring. Little is known on the presence of such parental effects in Anopheles.
Maung Liam, Grech Katrina, Read Andrew F
doaj   +1 more source

"Borrowing Constraints, Parental Altruism and Welfare" [PDF]

open access: yes
This paper investigates the impact of borrowing constraints on welfare in a standard overlapping-generations model where parental altruism results in transfers. I find that the average level of welfare is higher when children cannot borrow against future
Jorge Soares
core  

From "Adjuncts" to "Subjects" parental involvement in a working-class community [PDF]

open access: yes, 2001
This paper focuses on a project of parental involvement in a state primary school located in a predominantly working-class area in Malta. The authors are two of the project's coordinators.
Borg, Carmel, Mayo, Peter
core   +1 more source

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