Results 131 to 140 of about 809,266 (346)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Somatization in children and adolescents with headache: the role of attachment to parents [PDF]

, 2023
Alessia Renzi, Francesca Lionetti, Oliviero Bruni, Pasquale Parisi, Federica Galli   +4 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Social support experiences when growing up with a parent with Huntington’s disease [PDF]

, 2022
Siri Kjoelaas, Kristin Billaud Feragen, Tine K. Jensen   +2 more
openalex   +1 more source

Parenting Practices of Resident Fathers: The Role of Marital and Biological Ties [PDF]

This paper uses data from the Fragile Families and Child Wellbeing Study to examine differences in the parenting behaviors of resident biological and social fathers on measures of engagement, shared responsibility, and cooperation in parenting ...
Cynthia Osborne, Lawrence M. Berger, Marcia J. Carlson, Sharon H. Bzostek   +3 more
core  

Prepped for Success? Supporting Pregnant and Parenting Teens in Chicago Schools [PDF]

, 2003
In 2000, there were 8,153 births to mothers under the age of 20 in the city of Chicago. Forty-one percent of those births (3321) were to teenagers 17 or younger.
Helene M. Marcy
core  

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Teaching Latino Parents to Support the Multi-Symbol Message Productions of their Children who Require AAC [PDF]

, 2008
Cathy Binger, Jennifer Kent-Walsh, Jacqueline Berens, Stephanie Del Campo, Donna Rivera   +4 more
openalex   +1 more source

Parenting in the early years: effectiveness of parenting support programs for Indigenous families [PDF]

This resource sheet examines programs for Australian Indigenous families that effectively support parenting in the early years. This is not a systematic review of all programs; instead, it presents briefly on the evidence for parenting programs generally
Melinda Polimeni, Robyn Mildon
core