Results 141 to 150 of about 2,046,882 (412)

A Novel C19orf47‐AKT2 Chimeric RNA Generated by Cis‐Splicing of Adjacent Genes Is Associated With Glioblastoma Prognosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Malignant gliomas pose significant therapeutic challenges. This study aimed to identify and characterize a novel chimeric RNA in glioma and assess its clinical and functional significance for precision treatment. Methods The C19orf47‐AKT2 chimeric RNAs were identified through RNA sequencing and validated by polymerase chain reaction.
Zihan Wang   +11 more
wiley   +1 more source

Parenting in a time of COVID-19

open access: yesThe Lancet, 2020
L. Cluver   +14 more
semanticscholar   +1 more source

Remaining Burden of Spinal Muscular Atrophy Among Treated Patients: A Survey of Patients and Caregivers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal muscular atrophy (SMA) significantly impacts motor function. This study aimed to assess the persistent burden and unmet needs among currently treated patients with SMA and their caregivers. Methods Two complementary web‐based surveys were distributed in August 2024 among patients with SMA and their caregivers.
Julie A. Parsons   +8 more
wiley   +1 more source

No Place to Grow: The Unsafe and Unstable Housing Conditions of Illinois Pregnant and Parenting Youth and Their Children [PDF]

open access: yes, 2003
In an attempt to determine the number of pregnant and parenting youth in need of alternative living arrangements throughout Illinois, the Center for Impact Research (CIR), in collaboration with its working group members, conducted a statewide needs ...
Helene M. Marcy
core  

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos   +17 more
wiley   +1 more source

Teacher-student interactions as a pathway to strengthen working memory in primary school students: a microtrial study protocol

open access: yesFrontiers in Education
Executive function refers to a set of cognitive processes essential for effectively managing complex tasks and enabling goal-directed behavior. Working memory (WM), one of the core executive functions, is the ability to temporarily hold and manipulate ...
Sophie Pollé   +5 more
doaj   +1 more source

The importance of early parenting for later child outcomes: A study with Spanish families with children with disabilities [PDF]

open access: yes, 2018
Children with different disability conditions have varied developmental trajectories, which perhaps influences parent-child interaction. For these and all infants, an optimal home environment that includes good parenting and positive parent-child ...
Bersabe-Moran, Rosa Maria   +6 more
core  

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó   +17 more
wiley   +1 more source

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