Results 101 to 110 of about 2,412,793 (347)

Behavioral family intervention for children with developmental disabilities and behavioral problems [PDF]

, 2006
The outcomes of a randomized clinical trial of a new behavioral family intervention, Stepping Stones Triple P, for preschoolers with developmental and behavior problems are presented.
Bryant D., Clare Roberts, Gavidia-Payne S., Hawley D. R., Hollis S., Hudson A., Huynen K. B., Lisa Studman, Matthew R. Sanders, Quine L., Roberts C., Roberts C. M., Sanders M. R., Trevor Mazzucchelli   +13 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A formal evaluation of the performance of different corporate styles in stable and turbulent environments [PDF]

The notion of "parenting styles", introduced by Goold, Campbell and Alexander, has been widely acknowledged by the Corporate Strategy literature as a good broad description of the different ways in which corporate managers choose to manage and organize ...
Caldart, Adrian A., Ricart, Joan E.
core  

Effect of Play Group and Biopsychosocial Factors on the Independence Development of Preschool Children in Surakarta [PDF]

, 2017
Background: The development of children’s independence is important for their future competitiveness in the rapidly increasing social changes. Disturbance in the development of children’s independence may have a negative future impact in adult life and ...
Marlinawati, I. T. (Iin), Murti, B. (Bhisma), Salimo, H. (Harsono)   +2 more
core  

The influence of mothers' and fathers' parenting stress and depressive symptoms on own and partner's parent-child communication [PDF]

, 2013
This study examines how parenting stress and depressive symptoms experienced by mothers and fathers influence their own (actor effects) and the partner's (partner effects) parent–child communication. Based on the Actor-Partner Interdependence Model, data
Abidin, Abidin, Ackard, Almeida, American Psychiatric Association, Baril, Barnes, Beardslee, Belsky, Belsky, Bronte-Tinkew, Cabrera, Cooper, Cox, Crnic, Crnic, Cummings, Cummings, Davies, Deater-Deckard, Deater-Deckard, Dorn, Elgar, Erel, Fergusson, Gazendam-Donofrio, Gerris, Gerris, Goodman, Goodman, Goodman, Huizinga, Jackson, Jacob, Kenny, Kenny, Lamb, Ledermann, Lovejoy, Malmberg, McLeod, Middleton, Minuchin, Mitchell, Muthén, Nelson, Phares, Phares, Podsakoff, Radloff, Riesch, Schacht, Seginer, Semmer, Van de Velde, Van den Troost, Wilson   +56 more
core   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Parenting Style and Generativity Measured in College Students and Their Parents

SAGE Open, 2014
The logical consistency between generativity and the authoritative parenting style led to the hypothesis that the two behavior patterns or orientations were related.
Denise D. Guastello, Stephen J. Guastello, Jeralee M. Briggs   +2 more
doaj   +1 more source

Cross-sectional associations between maternal parenting styles, physical activity and screen sedentary time in children

BMC Public Health, 2017
Background Children’s activity level, including physical activity (PA) and screen sedentary time (SST), is influenced by environmental factors in which parents play a critical role.
K. E. Van der Geest, S. Y. M. Mérelle, G. Rodenburg, D. Van de Mheen, C. M. Renders   +4 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source