Results 191 to 200 of about 92,117 (241)

The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment

Epilepsia, EarlyView.
Abstract Objective Mutations of the DEP Domain Containing 5 gene (DEPDC5), a mechanistic Target of Rapamycin (mTOR) inhibitor involved in amino acid sensing, are associated with neurological diseases such as epilepsy and/or autism spectrum disorder (ASD). Loss of DEPDC5 impacts early neuronal development via mTOR hyperactivity.
Mattson S. O. Jones, Silvia Lindlar, Johannes Ludwig, Regina Waltes, Afsheen Kumar, Sophie v. Brauchitsch, Andrea Rossi, Evelyn Ullrich, Stefan Momma, Christine M. Freitag, Jasmin K. Hefendehl, Karl Martin Klein, Felix Rosenow, Denise Haslinger, Andreas G. Chiocchetti   +14 more
wiley   +1 more source

HD‐EEG source imaging with simultaneous SEEG recording in drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Objective This study aimed to assess the complementary role of high‐density electroencephalography (HD‐EEG)–based electrical source imaging (ESI) in localizing the seizure‐onset zone (SOZ) during ictal events and the irritative zone (IZ) during the interictal period, using simultaneous acquired stereo‐EEG (SEEG) recordings as a reference.
Shenglin Hao, Haifeng Zhao, Ziyi Feng, Wei Liu, Chao Zhang, Hang Ping, Qiang Zhou, Bomin Sun, Shikun Zhan, Chunyan Cao   +9 more
wiley   +1 more source

Familial adult myoclonus epilepsy: A comprehensive diagnostic strategy for clinical practice

Epilepsia, EarlyView.
Abstract Familial adult myoclonus epilepsy (FAME) is a genetic neurological disorder characterized by cortical myoclonus and epileptic seizures with clinical features that overlap with other movement disorders and epileptic syndromes, particularly essential tremor (ET), progressive myoclonic epilepsy (PME), and juvenile myoclonic epilepsy (JME).
Yitao Lu, Yi Ge, Ruyi Wang, Yang Zheng, Jiping Zhou, Zhongjin Wang, Chunhong Shen, Shan Wang, Lingli Hu, Bo Wang, Zhidong Cen, Wei Luo, Meiping Ding, Shuang Wang, Yao Ding   +14 more
wiley   +1 more source

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

Avoidance habit learning in adolescents and young women with anorexia nervosa: an fMRI study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Anorexia nervosa (AN), often with an onset in adolescence, is a complex eating disorder characterized by distorted body image, fear of weight gain, and extreme food restriction, leading to severe underweight. Excessive goal pursuit and avoidance behaviors have been proposed as key factors in AN, which over time may become over‐trained into ...
Julius Hennig, Ilka Boehm, Katharina Zwosta, Joseph A. King, Daniel Geisler, Hannes Ruge, Maria Seidel, Fabio Bernardoni, Inger Hellerhoff, Arne Doose, Sophie Pauligk, Henri Leschzinski, Veit Roessner, Uta Wolfensteller, Stefan Ehrlich   +14 more
wiley   +1 more source

Annual Research Review: Neural mechanisms of eating disorders in youth – from current theory and findings to future directions

Journal of Child Psychology and Psychiatry, EarlyView.
Eating disorders are prevalent and profoundly debilitating psychiatric conditions with multifactorial etiology that frequently manifest during adolescence. This developmental stage is characterized by significant neurostructural and neurofunctional change, which may create a context conducive to the emergence of eating pathology.
Kelsey Hagan, E. Caitlin Lloyd, Sasha Gorrell   +2 more
wiley   +1 more source

Molecular phylogeny reveals a new species of ghost electric knifefish Porotergus Ellis 1912 (Gymnotiformes: Apteronotidae), from the Amazon basin

Journal of Fish Biology, EarlyView.
Abstract A new species of ghost electric knifefish, Porotergus sambaibensis sp. nov., is described from the Javaés River, a tributary of the Araguaia River in Brazil. The new species was assigned to the genus Porotergus as the closest relative to Porotergus gimbeli through maximum likelihood reconstruction of a concatenated multilocus dataset ...
Marina B. Mendonça, Luiz A. W. Peixoto, Carine C. Chamon, A. Akama, C. David de Santana   +4 more
wiley   +1 more source

Assessing the intraspecific osteological variation of the spottail shiner (Hudsonius hudsonius) (Cypriniformes: Leuciscidae)

Journal of Fish Biology, EarlyView.
Abstract Hudsonius hudsonius (Cypriniformes: Leuciscidae), commonly known as the spottail shiner, is a small cyprinoid fish species found across much of North America. H. hudsonius has traditionally been regarded as one of the most basal and plesiomorphic species among the notropin fishes, that is, fishes traditionally placed in or associated with the ...
Erika K. Jessen
wiley   +1 more source

Two new species of stone loaches of the genus Barbatula (Cypriniformes: Nemacheilidae) from Europe with a neotype designation of B. barbatula (Teleostei: Nemacheilidae)

Journal of Fish Biology, EarlyView.
Abstract Ten species of Barbatula are recognised in Europe, west of the Urals: B. barbatula, B. caucasica, B. hispanica, B. leoparda, B. pironae, B. quignardi, B. sturanyi, B. taurica, B. vardarensis and B. zetensis, with B. caucasica and B. taurica formerly considered subspecies of B. barbatula.
Bárbara B. Calegari, Jörg Freyhof, Conor Waldock, Bernhard Wegscheider, Dario Josi, Lukas Rüber, Ole Seehausen   +6 more
wiley   +1 more source