Results 221 to 230 of about 98,141 (290)

Strain Traits of Intracranially Administered L‐Type Bovine Spongiform Encephalopathy Prions Are not Significantly Modified During Intraspecies Transmission in Cynomolgus Monkeys

open access: yesMicrobiology and Immunology, EarlyView.
ABSTRACT Among the three prion strains of bovine spongiform encephalopathy (BSE), classical BSE (C‐BSE) prions are known causative agents of variant Creutzfeldt–Jakob disease. By contrast, human infections with L‐type (L‐) or H‐type (H‐) BSE prions have not been reported.
Ken'ichi Hagiwara   +8 more
wiley   +1 more source

Electrophysiological sexual dimorphism as an early risk marker of alcohol use in adolescence: A longitudinal neuroimaging study

open access: yesAddiction, EarlyView.
Abstract Aims To identify the brain activity profiles associated with alcohol consumption and to address its causes. Furthermore, we sought to examine the relationship between these electrophysiological markers and the excitation–inhibition balance, as well as to explore the potential moderating role of sex in these associations.
Alberto del Cerro‐León   +9 more
wiley   +1 more source

Herpes Simplex Encephalitis of the Parietal Lobe: A Rare Presentation. [PDF]

open access: yesCureus, 2016
Fisahn C   +9 more
europepmc   +1 more source

Morphometric and Paleobiological Insights Into Pleistocene Sicilian Wolf Populations

open access: yesActa Zoologica, EarlyView.
ABSTRACT The Pleistocene wolves (Canis lupus) from Sicily represent one of the few known insular populations of this species from that time period. Despite their potential relevance for understanding carnivore adaptations in insular contexts, no dedicated study has previously investigated their morphology and evolutionary significance.
Domenico Tancredi   +3 more
wiley   +1 more source

A unified 3D reconstruction of microscopy and MRI in a brain showing Alzheimer's disease‐related neuropathology

open access: yesBrain Pathology, EarlyView.
Post mortem MRI was combined with neuropathological assessments at 600 μm intervals throughout the brain. Through this approach, a three dimensional account of an entire human brain with an intermediate Alzheimer's disease neuropathologic change was created.
Anneke Alkemade   +13 more
wiley   +1 more source

Sialylation patterns in cerebral amyloid angiopathy

open access: yesBrain Pathology, EarlyView.
This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau   +8 more
wiley   +1 more source

Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV‐1

open access: yesBrain Pathology, EarlyView.
Despite effective ART, neurocognitive impairment persists in people with HIV. Brains from PWH present exacerbated microgliosis and formation of microglial nodules that are actively engaged in neuronal phagocytosis, resulting in neuronal injury and dendritic loss.
Roberta S. Dos Reis   +12 more
wiley   +1 more source

Exploring Brain Parenchymal Changes in Acromegaly: Focus on White Matter Hyperintensities

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Introduction Acromegaly is a rare chronic disease caused by excessive secretion of growth hormone. Even with biochemical control, hormonal imbalance may lead to cerebral changes. This study aimed to evaluate the presence of white matter hyperintensities (WMHs) in patients with acromegaly.
Denise Costa   +7 more
wiley   +1 more source

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