Results 61 to 70 of about 4,352,696 (267)
From Baldwin’s Paris to Benjamin’s: The Architectonics of Race and Sexuality in Giovanni’s Room
Originally published in Architectural Theory Review 10, no. 1 (2005): 44–63.
Magdalena J. Zaborowska
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
After Paris: transitions for sustainable consumption
Consumption emissions-reduction measures based on an individualized model of consumption, marginal lifestyle changes, and technological innovation alone cannot meet the ambitions of the 2015 Paris Agreement to hold global temperature increases below 2 °C.
Daniel Welch, Dale Southerton
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
SOCIO-POLITICAL IDEAS AND SOCIAL CIRCLE OF TALLEYRAND ON THE EVE OF THE FRENCH REVOLUTION
The article characterizes a little-known period in the life of one of the major figures of the Great French Revolution - Charles Maurice Talleyrand. That was the time of his youth and the beginning of his career as a clergyman.
Samsarov A.I.
doaj +1 more source
Analyse onomastique des pseudonymes de prostituées parisiennes du XVIIIe au début du XXe siècle
Le présent article s’inscrit dans le contexte des recherches scientifiques dédiées à l’onomastique, plus particulièrement aux études sur l’anthroponymie, voire sur la pseudonymie, et répond au besoin actuel d’analyses onomastiques en romanistique.
Stéphane Hardy
doaj +1 more source
Emotional Outbursts and Their Effects on Peer Relations in the Preschool Classroom [PDF]
Emotions and emotion regulation play a role in a child’s interactions with their peers. This study uses observations collected in two preschool classrooms to address the questions of what causes emotional outbursts and how emotional outbursts affect the ...
Paris, Jordan
core +2 more sources
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source

