Results 61 to 70 of about 4,352,696 (267)

From Baldwin’s Paris to Benjamin’s: The Architectonics of Race and Sexuality in Giovanni’s Room

open access: yesJournal of Transnational American Studies, 2016
Originally published in Architectural Theory Review 10, no. 1 (2005): 44–63.
Magdalena J. Zaborowska
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

After Paris: transitions for sustainable consumption

open access: yesSustainability: Science, Practice, & Policy, 2019
Consumption emissions-reduction measures based on an individualized model of consumption, marginal lifestyle changes, and technological innovation alone cannot meet the ambitions of the 2015 Paris Agreement to hold global temperature increases below 2 °C.
Daniel Welch, Dale Southerton
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

SOCIO-POLITICAL IDEAS AND SOCIAL CIRCLE OF TALLEYRAND ON THE EVE OF THE FRENCH REVOLUTION

open access: yesВестник Брянского государственного университета
The article characterizes a little-known period in the life of one of the major figures of the Great French Revolution - Charles Maurice Talleyrand. That was the time of his youth and the beginning of his career as a clergyman.
Samsarov A.I.
doaj   +1 more source

Analyse onomastique des pseudonymes de prostituées parisiennes du XVIIIe au début du XXe siècle

open access: yesActa Universitatis Lodziensis: Folia Litteraria Romanica, 2021
Le présent article s’inscrit dans le contexte des recherches scientifiques dédiées à l’onomastique, plus particulièrement aux études sur l’anthroponymie, voire sur la pseudonymie, et répond au besoin actuel d’analyses onomastiques en romanistique.
Stéphane Hardy
doaj   +1 more source

Emotional Outbursts and Their Effects on Peer Relations in the Preschool Classroom [PDF]

open access: yes, 2019
Emotions and emotion regulation play a role in a child’s interactions with their peers. This study uses observations collected in two preschool classrooms to address the questions of what causes emotional outbursts and how emotional outbursts affect the ...
Paris, Jordan
core   +2 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

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