Results 211 to 220 of about 940,572 (293)

Individualized Atrophy‐Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed‐Effects Modeling

Annals of Neurology, EarlyView.
Objective Age of symptom onset is highly variable in familial frontotemporal lobar degeneration (f‐FTLD). Accurate prediction of onset would inform clinical management and trial enrollment. Prior studies indicate that individualized maps of brain atrophy can predict conversion to dementia in f‐FTLD.
Shubir Dutt, Dana Leichter, Yann Cobigo, Amy Wolf, John Kornak, Annie Clark, Lucy L. Russell, Arabella Bouzigues, David M. Cash, Martina Bocchetta, Molly Olzinski, Brian Appleby, Ece Bayram, Barbara Borroni, Andrea Bozoki, Chris R. Butler, David Clark, Rhian S. Convery, R. Ryan Darby, Alexandre de Mendonça, Bradford Dickerson, Kimiko Domoto‐Reilly, Simon Ducharme, Eve Ferry‐Bolder, Elizabeth Finger, Phoebe H. Foster, Douglas R. Galasko, Daniela Galimberti, Alexander Gerhard, Nupur Ghoshal, Caroline Graff, Neill Graff‐Radford, Ian M. Grant, Chadwick M. Hales, Lawrence S. Honig, Ging‐Yuek Hsiung, Edward D. Huey, David Irwin, Lize C. Jiskoot, Walter Kremers, Justin Y. Kwan, Robert Laforce, Isabelle Le Ber, Gabriel C. Léger, Johannes Levin, Irene Litvan, Ian R. Mackenzie, Mario Masellis, Mario F. Mendez, Fermin Moreno, Chiadi Onyike, Markus Otto, Belen Pascual, Peter Pressman, Rosa Rademakers, Eliana Marisa Ramos, Aaron Ritter, Erik D. Roberson, James B. Rowe, Raquel Sanchez‐Valle, Isabel Santana, Harro Seelaar, Allison Snyder, Sandro Sorbi, Matthis Synofzik, Maria Carmela Tartaglia, Pietro Tiraboschi, John C. van Swieten, Marijne Vandebergh, Rik Vandenberghe, Hilary W. Heuer, Bruce L. Miller, William W. Seeley, Maria Luisa Gorno‐Tempini, Joel H. Kramer, Leah Forsberg, Kejal Kantarci, Bradley F. Boeve, Adam L. Boxer, Jonathan D. Rohrer, Howard J. Rosen, Adam M. Staffaroni, FTD Prevention Initiative (FPI) investigators   +82 more
wiley   +1 more source

From Microscale to Nanoscale Shadow Electrochemiluminescence Microscopy

Angewandte Chemie, EarlyView.
In this research we report on the label‐free shadow electrochemiluminescence (shadow ECL) microscopy of microscale and nanoscale objects. By systematically investigating various influencing factors—including optical configuration, electrode activity, frame averaging, exposure time, and particle arrangement—we further confirm the nano‐imaging potential ...
Xiaodan Gou, Hanna Manko, Jasmina Vidic, Laurent Cognet, Jun‐Jie Zhu, Neso Sojic   +5 more
wiley   +2 more sources

Alternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target

Annals of Neurology, EarlyView.
Objective Biallelic variants in PRKN cause autosomal recessive Parkinson's disease (PD) with a median age at onset of 31 years. When evaluating the 16 previously published carriers of a homozygous deletion of Exon 2 from the International Parkinson's Disease and Movement Disorder Society Gene Database (MDSGene) database, the median age at onset is ...
Arian Hach, Katja Lohmann, Manabu Funayama, Poornima J. Menon, Eva‐Juliane Vollstedt, Teresa Kleinz, Hiroyo Yoshino, Suzanne Lesage, Britta Meier, Carolyn M. Sue, Jean‐Christophe Corvol, Alexis Brice, Nobutaka Hattori, Christine Klein, Aleksandar Rakovic   +14 more
wiley   +1 more source

Low‐Temperature Reverse Water–Gas Shift Enabled by Magnetically Induced Catalysis

Angewandte Chemie, EarlyView.
Magnetically induced catalysis using standard Cu–Al spinel‐derived catalyst functionalized with carbon‐coated iron nanoparticles enables high CO yield (up to 62%) at mild catalyst and reactor temperatures (estimated at 300°C and determined as 25–123°C, respectively).
Junhui Hu, Lise Marie Lacroix, Jacob Johny, Sourav Ghosh, Elisabeth Hannah Wolf, Jeongmin Ji, Sheng‐Hsiang Lin, Manisha Durai, Alin Benice Schöne, Walid Hetaba, Holger Ruland, Walter Leitner, Alexis Bordet   +12 more
wiley   +2 more sources

Novel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture Media

Annals of Neurology, EarlyView.
Objective Aqueously diffusible oligomers of the amyloid β‐protein (oAβ) are neurotoxic and play a role in neuronal dysfunction in Alzheimer's disease (AD). Accurate quantification of oAβ in brains and biofluids could be valuable for understanding and monitoring AD.
Yi Ran Xu, Youqi Tao, Alexandra M. Lish, Shaomin Li, Beth L. Ostaszewski, Amirah K. Anderson, Tracy Young‐Pearse, Trebor L. Lawton, Hyun‐Sik Yang, Dominic M. Walsh, Ting Yang, Dennis J. Selkoe   +11 more
wiley   +1 more source

Extended Fused Carbazole‐BODIPY, High Brightness NIR Organic Dyes

Angewandte Chemie, EarlyView.
Highly fused boron‐dipyrromethene (BODIPY) with a strong donor group has been synthesized, and their photophysical behaviors fully characterized. They exhibit outstanding brightness for fluorophores emitting in the NIR region. Water‐soluble nanoparticles filled with one of these dyes demonstrate high efficiency as the NIR II visualization agent ...
Fabien Ceugniet, Valentin Ott, Pascal Retailleau, Yann Bretonniere, Olivier Maury, Manon H. E. Bousquet, Lucie Sancey, Nicolas Leclerc, Denis Jacquemin, Gilles Ulrich   +9 more
wiley   +2 more sources

Self-preservation strategy for approaching global warming targets in the post-Paris Agreement era. [PDF]

Nat Commun, 2020
Wei YM, Han R, Wang C, Yu B, Liang QM, Yuan XC, Chang J, Zhao Q, Liao H, Tang B, Yan J, Cheng L, Yang Z.   +12 more
europepmc   +1 more source

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, EarlyView.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

Induced Photoelectron Circular Dichroism as a Probe for Distinguishing Diastereotopic Lone Electron Pairs

Angewandte Chemie, EarlyView.
Gas‐phase complexation of chiral methyloxirane by achiral phenol results in induced chiroptical response of phenol. Two pseudo enantiomer complexes are observed, corresponding to hydrogen bonding from phenol to either of the lone electron pair of the methyloxirane oxygen, denoted as Pro R and Pro S, with opposite chiral deformation of phenol and ...
Etienne Rouquet, Valéria Lepère, Gustavo A. Garcia, Laurent Nahon, Rodolphe Vuilleumier, Anne Zehnacker   +5 more
wiley   +2 more sources

Total Synthesis of the Spirocyclic Bis‐Indole Alkaloid (−)‐Owerreine via a [4+2] Annulation

Angewandte Chemie, EarlyView.
The total synthesis of the bis‐indole alkaloid (−)‐owerreine has been accomplished by a diastereoselective [4+2] annulation between an enamine and an α,β−unsaturated indolenine precursor to form the 3‐spirocyclic tetrahydropyridine linkage of the natural product. DFT calculations allow an understanding of the mechanism of the key annulation.
Elisa Coll, Vincent Gandon, Cyrille Kouklovsky, Laurent Evanno, Guillaume Vincent   +4 more
wiley   +2 more sources