Results 41 to 50 of about 7,271,399 (244)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Keberhasilan Ratifikasi Amerika Serikat-Tiongkok atas Paris Agreement dalam Meningkatkan Legitimasi Rezim Mitigasi Global Climate Change [PDF]
, 2018 Dunia internasional merespon isu global climate change dengan membentuk rezim-rezim untuk melancarkan upaya mitigasi global climate change, yaitu Protokol Kyoto 1997, dan Paris Agreement 2015.
Fahri Syadia Fa’iz, 071411233001
core +1 more source
The role of carbon budgets in translating the Paris Agreement into national climate policy [PDF]
, 2020 Two articles of the Paris Agreement are particularly relevant to countries as they seek to mitigate their impact on global warming. Article 2 sets a target for long-term temperature stabilisation, seeking to hold the increase in global average ...
Daly, Hannah +5 more
core +2 more sources
Practical guidance towards consistent use of overshoot terminology
Environmental Research LettersAs global warming approaches 1.5 °C, the term ‘overshoot’ is becoming increasingly prominent in climate science, policy, and public communication, but the use of this term remains inconsistent and often ambiguous.
Joeri Rogelj +3 more
doaj +1 more source
Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
The Impact of U.S. Re‐engagement in Climate on the Paris Targets
Earth's Future, 2021 The Paris Agreement seeks to combine international efforts to keep global temperature increase to well‐below 2°C. Whilst current ambitions in many signatories are insufficient to achieve this goal, optimism prevailed in the second half of 2020.
Dirk‐Jan van de Ven +10 more
doaj +1 more source
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
The Paris Agreement: Reflections on an International Law Odyssey [PDF]
, 2017 This paper discusses how international law has responded to climate change, focusing on challenges that have faced the implementation of existing climate treaties, and on the suitability of the Paris Agreement to address these.
Annalisa Savaresi, Savaresi, Annalisa
core +1 more source
Breaking the Standoff: Post-2020 climate finance in the Paris agreement [PDF]
, 2014 Climate finance is fundamental to a fair and effective global climate agreement. Too few countries have delivered on their obligations. As a result, the world's poorest people have not benefitted from the necessary investment, and climate finance has ...
Gore, Tim +4 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes +75 more
wiley +1 more source