Results 31 to 40 of about 56,043 (264)

Association between driving and depression in older adults: findings from an ancillary study of a prospective cohort

BMC Geriatrics
Background Depression is prevalent among older adults, particularly those with somatic comorbidities, and is linked to cognitive decline and reduced quality of life.
Edouard Baudouin, R. Colle, L. Becquemont, E. Corruble, E. Duron   +4 more
doaj   +1 more source

An unexpected effect of TNF-α on F508del-CFTR maturation and function [v2; ref status: indexed, http://f1000r.es/5tv]

F1000Research, 2015
Cystic fibrosis (CF) is a multifactorial disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which encodes a cAMP-dependent Cl- channel.
Sara Bitam, Iwona Pranke, Monika Hollenhorst, Nathalie Servel, Christelle Moquereau, Danielle Tondelier, Aurélie Hatton, Valérie Urbach, Isabelle Sermet-Gaudelus, Alexandre Hinzpeter, Aleksander Edelman   +10 more
doaj   +1 more source

Does women’s place of birth affect their opportunity for an informed choice about Down syndrome screening? A population-based study in France

BMC Pregnancy and Childbirth, 2021
Background To examine disparities by maternal place of birth in the opportunity to make an informed choice about Down syndrome screening, in France, where the national guidelines recommend that physicians offer it to all pregnant women.
Olivia Anselem, Marie-Josèphe Saurel-Cubizolles, Babak Khoshnood, Béatrice Blondel, Priscille Sauvegrain, Nathalie Bertille, Elie Azria, for the BiP study group   +7 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, EarlyView.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

Complex context relationships between DNA methylation and accessibility, histone marks, and hTERT gene expression in acute promyelocytic leukemia cells: perspectives for all‐trans retinoic acid in cancer therapy

Molecular Oncology, 2020
Telomerase (hTERT) reactivation and sustained expression is a key event in the process of cellular transformation. Therefore, the identification of the mechanisms regulating hTERT expression is of great interest for the development of new anticancer ...
Delphine Garsuault, Claire Bouyer, Eric Nguyen, Rohan Kandhari, Martina Prochazkova‐Carlotti, Edith Chevret, Patricia Forgez, Evelyne Ségal‐Bendirdjian   +7 more
doaj   +1 more source

Enrichment Bayesian design for randomized clinical trials using categorical biomarkers and a binary outcome

BMC Medical Research Methodology, 2022
Background Adaptive clinical trials have been increasingly commonly employed to select a potential target population for one trial without conducting trials separately.
Valentin Vinnat, Sylvie Chevret
doaj   +1 more source

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source

Low‐Temperature Reverse Water–Gas Shift Enabled by Magnetically Induced Catalysis

Angewandte Chemie, EarlyView.
Magnetically induced catalysis using standard Cu–Al spinel‐derived catalyst functionalized with carbon‐coated iron nanoparticles enables high CO yield (up to 62%) at mild catalyst and reactor temperatures (estimated at 300°C and determined as 25–123°C, respectively).
Junhui Hu, Lise Marie Lacroix, Jacob Johny, Sourav Ghosh, Elisabeth Hannah Wolf, Jeongmin Ji, Sheng‐Hsiang Lin, Manisha Durai, Alin Benice Schöne, Walid Hetaba, Holger Ruland, Walter Leitner, Alexis Bordet   +12 more
wiley   +2 more sources

The Limits and Avoidance of Biases in Metagenomic Analyses of Human Fecal Microbiota

Microorganisms, 2020
An increasing body of evidence highlights the role of fecal microbiota in various human diseases. However, more than two-thirds of fecal bacteria cannot be cultivated by routine laboratory techniques.
Emma Bergsten, Denis Mestivier, Iradj Sobhani   +2 more
doaj   +1 more source